Phenotypes associated with this allele

• Allele Symbol: Nrep^tm1Wcw
• Allele Name: targeted mutation 1, William C Wetsel
• Allele ID: MGI:4353245
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nrep^tm1Wcw/Nrep^tm1Wcw	involves: 129S1/Sv * C57BL/6NCrl	MGI:4353272

Genotype
MGI:4353272

hm1

• Allelic Composition: Nrep^tm1Wcw/Nrep^tm1Wcw
• Genetic Background: involves: 129S1/Sv * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:151154 )

• mice reduce freezing in response to contextual fear conditioning with foot shock compared with similarly treated wild-type mice

abnormal olfactory discrimination memory ( J:151154 )

• mice spend less time with male urine and more time with saline than wild-type mice

• however, mice can distinguish between male urine and saline

impaired social transmission of food preference ( J:151154 )

• at 20 minutes and 24 hours from exposure to demonstrator mouse

abnormal spatial learning ( J:151154 )

• in a Morris water maze, mice exhibit impaired learning the location of the hidden platform compared with wild-type mice

abnormal grooming behavior ( J:151154 )

• fewer mice exhibit barbering compared to wild-type

abnormal motor capabilities/coordination/movement ( J:151154 )

• when suspended by their tails, mice spend more time immobile than wild-type mice

abnormal motor coordination/balance ( J:151154 )

• latency and duration of pole-walking are increased compared to in wild-type mice

impaired swimming ( J:151154 )

• swimming velocity in a Morris water maze is reduced during the first trial compared to in wild-type mice

• however, swimming velocity in the next three trials is normal