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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CTSG-RARA/PML)2544Ley
transgene insertion 2544, Timothy Ley
MGI:4353271
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(CTSG-PML/RARA)135Ley/0
Tg(CTSG-RARA/PML)2544Ley/0 		involves: C3H * C57BL/6 MGI:4353301
tg2
 		Tg(CTSG-RARA/PML)2544Ley/0 involves: C3H * C57BL/6 MGI:4353339


Genotype
MGI:4353301
cx1
Allelic
Composition		 Tg(CTSG-PML/RARA)135Ley/0
Tg(CTSG-RARA/PML)2544Ley/0
Genetic
Background		 involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CTSG-PML/RARA)135Ley mutation (1 available)
Tg(CTSG-RARA/PML)2544Ley mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased acute promyelocytic leukemia incidence ( J:59080 )
• 7 of 36 (19.4%) and 16 of 28 (57%) doubly transgenic mice of independent cohorts developed acute premyelocytic leukemia (APML) b7 of 36 (19.4%) and 16 of 28 (57%) doubly transgenic mice of independent cohorts developed acute premyelocytic leukemia (APML) by 12 and 24 months of age, respectively




Genotype
MGI:4353339
tg2
Allelic
Composition		 Tg(CTSG-RARA/PML)2544Ley/0
Genetic
Background		 involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:59080 )
N
• this transgene alone does not cause leukemia; more than 40 transgenic mice aged longer than 2 years failed to exhibit clinical or histologic evidence of the disease




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory