About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ets2tm5.1Rgo
targeted mutation 5.1, Robert G Oshima
MGI:4353393
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ets2tm5.1Rgo/Ets2tm5.1Rgo
Meox2tm1(cre)Sor/Meox2+ 		involves: 129/Sv * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:4353413
cn2
 		Ets1tm1Jml/Ets1tm1Jml
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:4353414
cn3
 		Ets1tm1Jml/Ets1tm1Jml
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Tg(Tek-cre)1Ywa/0 		involves: 129S/SvEv * C57BL/6 * FVB/N MGI:4353416
cn4
 		Ets2tm1Rgo/Ets2tm5.1Rgo
Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(S100a4-cre)1Gle/0 		involves: 129S2/SvPas * FVB/N MGI:4366764
cn5
 		Ets2tm1Rgo/Ets2tm5.1Rgo
Tg(MMTV-PyVT)634Mul/0
Tg(S100a4-cre)1Gle/0 		involves: 129S2/SvPas * FVB/N MGI:4366767
cn6
 		Ets2tm1Rgo/Ets2tm5.1Rgo
Tg(S100a4-cre)1Gle/0 		involves: 129S2/SvPas * FVB/N MGI:4366768


Genotype
MGI:4353413
cn1
Allelic
Composition		 Ets2tm5.1Rgo/Ets2tm5.1Rgo
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129/Sv * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (39 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:151187 )
N
• viable unlike homozygous null mice

integument




Genotype
MGI:4353414
cn2
Allelic
Composition		 Ets1tm1Jml/Ets1tm1Jml
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm1Jml mutation (0 available); any Ets1 mutation (28 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (39 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:151187 )
• die between E11.5 and E15.5

cardiovascular system
hemorrhage ( J:151187 )
• seen at E11.5 in some embryos

homeostasis/metabolism
edema ( J:151187 )
• seen at E11.5 in some embryos




Genotype
MGI:4353416
cn3
Allelic
Composition		 Ets1tm1Jml/Ets1tm1Jml
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm1Jml mutation (0 available); any Ets1 mutation (28 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (39 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cellular
increased vascular endothelial cell apoptosis ( J:151187 )
• increase in endothelial cell apoptosis at E11.5 and E13.5

cardiovascular system
abnormal vascular branching morphogenesis ( J:151187 )
• defect in branching seen at E10.5 and E11.5
• increase in inter blood vessel spacing
increased vascular endothelial cell apoptosis ( J:151187 )
• increase in endothelial cell apoptosis at E11.5 and E13.5




Genotype
MGI:4366764
cn4
Allelic
Composition		 Ets2tm1Rgo/Ets2tm5.1Rgo
Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(S100a4-cre)1Gle/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm1Rgo mutation (1 available); any Ets2 mutation (39 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (39 available)
Ptentm1.1Mwst mutation (0 available); any Pten mutation (88 available)
Tg(S100a4-cre)1Gle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased mammary gland tumor incidence ( J:153747 )
• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(S100a4-cre)1Gle mice
increased mammary gland tumor incidence ( J:153747 )
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes
abnormal tumor morphology ( J:153747 )
• mammary tumors induced by NT2.5 exhibit decreased numbers of macrophages and recruitment of new vasculature compared to in similarly treated Ptentm1.1Mwst homozygotes

integument
decreased mammary gland tumor incidence ( J:153747 )
• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(S100a4-cre)1Gle mice
increased mammary gland tumor incidence ( J:153747 )
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes

endocrine/exocrine glands
decreased mammary gland tumor incidence ( J:153747 )
• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(S100a4-cre)1Gle mice
increased mammary gland tumor incidence ( J:153747 )
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes




Genotype
MGI:4366767
cn5
Allelic
Composition		 Ets2tm1Rgo/Ets2tm5.1Rgo
Tg(MMTV-PyVT)634Mul/0
Tg(S100a4-cre)1Gle/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm1Rgo mutation (1 available); any Ets2 mutation (39 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (39 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
Tg(S100a4-cre)1Gle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased mammary gland tumor incidence ( J:153747 )
• fewer mammary tumors form than in Ets2tm1Rgo/Ets2tm5.1Rgo Tg(MMTV-PyVT)634Mul mice and progression to adenoma and early carcinoma is slowed

integument
decreased mammary gland tumor incidence ( J:153747 )
• fewer mammary tumors form than in Ets2tm1Rgo/Ets2tm5.1Rgo Tg(MMTV-PyVT)634Mul mice and progression to adenoma and early carcinoma is slowed

endocrine/exocrine glands
decreased mammary gland tumor incidence ( J:153747 )
• fewer mammary tumors form than in Ets2tm1Rgo/Ets2tm5.1Rgo Tg(MMTV-PyVT)634Mul mice and progression to adenoma and early carcinoma is slowed




Genotype
MGI:4366768
cn6
Allelic
Composition		 Ets2tm1Rgo/Ets2tm5.1Rgo
Tg(S100a4-cre)1Gle/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm1Rgo mutation (1 available); any Ets2 mutation (39 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (39 available)
Tg(S100a4-cre)1Gle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:153747 )
N
• mice exhibit normal mammary gland development




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory