About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Themis5AT161
5AT161
MGI:4353412
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Themis5AT161/Themis5AT161 involves: C57BL/6 MGI:4353422
cx2
 		Rag2tm1Fwa/Rag2tm1Fwa
Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Themis5AT161/Themis5AT161 		involves: 129S/SvEv * C57BL/6 MGI:4353423
cx3
 		Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Themis5AT161/Themis5AT161 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:4353424


Genotype
MGI:4353422
hm1
Allelic
Composition		 Themis5AT161/Themis5AT161
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Themis5AT161 mutation (0 available); any Themis mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:151076 )
• there is a lower percentage of CD44loCD4+ T cells in the blood than in controls
• nave CD4 T cell population is only 12% that of controls
decreased CD8-positive, alpha-beta T cell number ( J:151076 )
• the nave CD8 T cell population is 30% of that in controls
decreased regulatory T cell number ( J:151076 )
• regulatory T cell numbers are decreased more in the thymus than the CD4 single positive thymocyte population
decreased single-positive T cell number ( J:151076 )
• the CD4 and CD8 single-positive thymocyte populations are significantly smaller than in controls
• significant loss in the immature CD4+ subset in the thymus

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:151076 )
• there is a lower percentage of CD44loCD4+ T cells in the blood than in controls
• nave CD4 T cell population is only 12% that of controls
decreased CD8-positive, alpha-beta T cell number ( J:151076 )
• the nave CD8 T cell population is 30% of that in controls
decreased regulatory T cell number ( J:151076 )
• regulatory T cell numbers are decreased more in the thymus than the CD4 single positive thymocyte population
decreased single-positive T cell number ( J:151076 )
• the CD4 and CD8 single-positive thymocyte populations are significantly smaller than in controls
• significant loss in the immature CD4+ subset in the thymus




Genotype
MGI:4353423
cx2
Allelic
Composition		 Rag2tm1Fwa/Rag2tm1Fwa
Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Themis5AT161/Themis5AT161
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
Tg(Tcra5CC7,Tcrb5CC7)IWep mutation (5 available)
Themis5AT161 mutation (0 available); any Themis mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased double-positive T cell number ( J:151076 )
• an increase in double positive thymocytes results from arrested thymocyte development
arrested T cell differentiation ( J:151076 )
• there is a complete block in CD4 single-positive thymocyte development
• the minor CD8 single-positive population in transgenic mice is also significantly affected

immune system
increased double-positive T cell number ( J:151076 )
• an increase in double positive thymocytes results from arrested thymocyte development
arrested T cell differentiation ( J:151076 )
• there is a complete block in CD4 single-positive thymocyte development
• the minor CD8 single-positive population in transgenic mice is also significantly affected




Genotype
MGI:4353424
cx3
Allelic
Composition		 Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Themis5AT161/Themis5AT161
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (4 available)
Themis5AT161 mutation (0 available); any Themis mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased single-positive T cell number ( J:151076 )
• CD8 single-positive thymocytes are reduced in female mice compared to transgenic controls

immune system
decreased single-positive T cell number ( J:151076 )
• CD8 single-positive thymocytes are reduced in female mice compared to transgenic controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory