Phenotypes associated with this allele

• Allele Symbol: Grm5^tm1.1Kksz
• Allele Name: targeted mutation 1.1, Karen K Szumlinski
• Allele ID: MGI:4353518
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grm5^tm1.1Kksz/Grm5^tm1.1Kksz	involves: 129S1/Sv * 129X1/SvJ	MGI:5461826
hm2	Grm5^tm1.1Kksz/Grm5^tm1.1Kksz	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:4353623

Genotype
MGI:5461826

hm1

• Allelic Composition: Grm5^tm1.1Kksz/Grm5^tm1.1Kksz
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal nociception after inflammation ( J:191366 )

♂ • formalin-treated mice exhibit greater response to pain during the second phase, but not the first phase, compared with wild-type mice

Genotype
MGI:4353623

hm2

• Allelic Composition: Grm5^tm1.1Kksz/Grm5^tm1.1Kksz
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

behavior/neurological

decreased alcohol consumption ( J:151084 )

• using a scheduled high alcohol consumption model, mice exhibit a 75% reduction in binge alcohol consumption compared with wild-type mice

• however, no difference in alcohol consumption was observed in a model of voluntary alcohol preference drinking or when mice are pre-treated via the intra-nucleus accumbens with MPEP or wortmannin