All Phenotypes Asic3<tm1Pho> MGI Mouse

abnormal retina apoptosis ( J:151049 )

• apoptosis in the outer and inner nuclear layer of the retina in mice over 8 months of age

amacrine cell degeneration ( J:151049 )

• degradation of oscillatory potential as mice age suggests dysfunction of amacrine cells

• amacrine cells without nuclei are observed in mice at 16 months of age

• high amounts of apoptosis occur to retinal amacrine cells after 8 months of age

retina ganglion cell degeneration ( J:151049 )

• ganglion cells in a degenerate state (i.e. lacking nuclei) are observed in the retinas of mice at 16 months of age

• high amounts of apoptosis occur to retinal ganglion cells after 8 months of age

photoreceptor inner segment degeneration ( J:151049 )

• the inner segment layer less organized as the mice age

• some vacuolated areas also appear in this layer as the mice age

• massive cell death by 16 months of age leads to large vacuolated areas

photoreceptor outer segment degeneration ( J:151049 )

• the outer segment layer in mice becomes thicker and less organized as the mice age

• some vacuolated areas appear in this layer as the mice age

disorganized retina inner nuclear layer ( J:151049 )

• the inner nuclear layer becomes thinner by 16 months of age

disorganized retina outer nuclear layer ( J:151049 )

• the outer nuclear layer becomes disorganized as mice age

retina outer nuclear layer degeneration ( J:151049 )

• the outer nuclear layer becomes thinner by 16 months of age

thin retina outer plexiform layer ( J:151049 )

• the outer plexiform layer becomes thinner by 16 months of age

abnormal eye electrophysiology ( J:151049 )

• oscillatory potential is impaired in mice as they age

abnormal rod electrophysiology ( J:151049 )

• 3-month old mice have enhanced scoptic a-wave with a maximum amplitude difference of 19.3%

• a-wave amplitudes decrease with age so that maximum amplitude is decreased by 18%, 40%, and 69% of controls at 8, 12, and 16 months of age, respectively

• genotype effect on b-wave amplitudes is attributed to rod cell defects because no differences are seen under photobleaching conditions

• 3-month old mice have enhanced scoptic b-wave with a maximum amplitude difference of 17.6%

• b-wave amplitudes decrease with age so that maximum amplitude is decreased by 21%, 32%, and 64% of controls at 8, 12, and 16 months of age, respectively

abnormal sensory neuron morphology ( J:151049 )