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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Szt2m1Frk
mutation 1, Wayne N Frankel
MGI:4353995
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Szt2m1Frk/Szt2m1Frk C57BL/6J-Szt2m1Frk MGI:4353997
hm2
 		Szt2m1Frk/Szt2m1Frk involves: BALB/cByJ * C57BL/6J MGI:4353998
ht3
 		Szt2Gt(XH662)Byg/Szt2m1Frk involves: 129P2/OlaHsd * C57BL/6J MGI:4354001


Genotype
MGI:4353997
hm1
Allelic
Composition		 Szt2m1Frk/Szt2m1Frk
Genetic
Background		 C57BL/6J-Szt2m1Frk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Szt2m1Frk mutation (2 available); any Szt2 mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:150942 )
N
• no motor abnormalities are detected
abnormal kindling response ( J:150942 )
• decrease in the latency to first seizure in males compared to controls using a repetitive non-invasive kindling assay
minimal clonic seizures ( J:150942 )
• increased sensitivity to electrically induced minimal clonic seizures
• however, mice do not exhibit spontaneous or handling provoked seizures

nervous system
nervous system phenotype ( J:150942 )
N
• no electroencephalographic or neurosensory abnormalities are detected
abnormal kindling response ( J:150942 )
• decrease in the latency to first seizure in males compared to controls using a repetitive non-invasive kindling assay
minimal clonic seizures ( J:150942 )
• increased sensitivity to electrically induced minimal clonic seizures
• however, mice do not exhibit spontaneous or handling provoked seizures




Genotype
MGI:4353998
hm2
Allelic
Composition		 Szt2m1Frk/Szt2m1Frk
Genetic
Background		 involves: BALB/cByJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Szt2m1Frk mutation (2 available); any Szt2 mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased susceptibility to pharmacologically induced seizures ( J:150942 )
• shorter latency to PTZ-induced tonic-clonic seizures compared to controls
minimal clonic seizures ( J:150942 )
• increased sensitivity to electrically induced minimal clonic seizures
tonic-clonic seizures ( J:150942 )
• shorter latency to PTZ-induced tonic-clonic seizures compared to controls

nervous system
increased susceptibility to pharmacologically induced seizures ( J:150942 )
• shorter latency to PTZ-induced tonic-clonic seizures compared to controls
minimal clonic seizures ( J:150942 )
• increased sensitivity to electrically induced minimal clonic seizures
tonic-clonic seizures ( J:150942 )
• shorter latency to PTZ-induced tonic-clonic seizures compared to controls




Genotype
MGI:4354001
ht3
Allelic
Composition		 Szt2Gt(XH662)Byg/Szt2m1Frk
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Szt2Gt(XH662)Byg mutation (2 available); any Szt2 mutation (94 available)
Szt2m1Frk mutation (2 available); any Szt2 mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
minimal clonic seizures ( J:150942 )
• increased incidence of electrically induced seizures compared to controls

nervous system
minimal clonic seizures ( J:150942 )
• increased incidence of electrically induced seizures compared to controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/17/2024
MGI 6.24 		The Jackson Laboratory