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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Szt2Gt(XH662)Byg
gene trap XH662, BayGenomics
MGI:4353996
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Szt2Gt(XH662)Byg/Szt2Gt(XH662)Byg (B6.129P2-Szt2Gt(XH662)Byg x 129S1.129P2-Szt2Gt(XH662)Byg)F1 MGI:4354000
hm2
 		Szt2Gt(XH662)Byg/Szt2Gt(XH662)Byg 129S1.129P2(B6)-Szt2Gt(XH662)Byg/FrkJ MGI:4353999
hm3
 		Szt2Gt(XH662)Byg/Szt2Gt(XH662)Byg B6.129P2-Szt2Gt(XH662)Byg/FrkJ MGI:4354002
ht4
 		Szt2Gt(XH662)Byg/Szt2+ involves: 129P2/OlaHsd * C57BL/6J MGI:4356430
ht5
 		Szt2Gt(XH662)Byg/Szt2m1Frk involves: 129P2/OlaHsd * C57BL/6J MGI:4354001


Genotype
MGI:4354000
hm1
Allelic
Composition		 Szt2Gt(XH662)Byg/Szt2Gt(XH662)Byg
Genetic
Background		 (B6.129P2-Szt2Gt(XH662)Byg x 129S1.129P2-Szt2Gt(XH662)Byg)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Szt2Gt(XH662)Byg mutation (2 available); any Szt2 mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:150942 )
• when examined at weaning only about 10% of the expected number of homozygotes are found




Genotype
MGI:4353999
hm2
Allelic
Composition		 Szt2Gt(XH662)Byg/Szt2Gt(XH662)Byg
Genetic
Background		 129S1.129P2(B6)-Szt2Gt(XH662)Byg/FrkJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Szt2Gt(XH662)Byg mutation (2 available); any Szt2 mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:150942 )
• when examined at weaning only about 10% of the expected number of homozygotes are found
preweaning lethality, incomplete penetrance ( J:150942 )
• when examined at weaning only about 10% of the expected number of homozygotes are found

behavior/neurological
maximal tonic hindlimb extension seizures ( J:150942 )
• several mice went past the minimal clonic seizure endpoint proceeding directly to tonic hindlimb extension
minimal clonic seizures ( J:150942 )
• increased sensitivity to electrically induced minimal clonic seizures

pigmentation
diluted coat color ( J:150942 )
• slightly diluted coat color

nervous system
maximal tonic hindlimb extension seizures ( J:150942 )
• several mice went past the minimal clonic seizure endpoint proceeding directly to tonic hindlimb extension
minimal clonic seizures ( J:150942 )
• increased sensitivity to electrically induced minimal clonic seizures

integument
diluted coat color ( J:150942 )
• slightly diluted coat color




Genotype
MGI:4354002
hm3
Allelic
Composition		 Szt2Gt(XH662)Byg/Szt2Gt(XH662)Byg
Genetic
Background		 B6.129P2-Szt2Gt(XH662)Byg/FrkJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Szt2Gt(XH662)Byg mutation (2 available); any Szt2 mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:150942 )
• no homozygotes are detected at weaning




Genotype
MGI:4356430
ht4
Allelic
Composition		 Szt2Gt(XH662)Byg/Szt2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Szt2Gt(XH662)Byg mutation (2 available); any Szt2 mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
minimal clonic seizures ( J:150942 )
• slight increase in the incidence of electrically induced seizures compared to controls

nervous system
minimal clonic seizures ( J:150942 )
• slight increase in the incidence of electrically induced seizures compared to controls




Genotype
MGI:4354001
ht5
Allelic
Composition		 Szt2Gt(XH662)Byg/Szt2m1Frk
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Szt2Gt(XH662)Byg mutation (2 available); any Szt2 mutation (94 available)
Szt2m1Frk mutation (2 available); any Szt2 mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
minimal clonic seizures ( J:150942 )
• increased incidence of electrically induced seizures compared to controls

nervous system
minimal clonic seizures ( J:150942 )
• increased incidence of electrically induced seizures compared to controls




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory