Phenotypes associated with this allele

• Allele Symbol: Ip6k2^tm1Dlin
• Allele Name: targeted mutation 1, D J Lindner
• Allele ID: MGI:4354090
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ip6k2^tm1Dlin/Ip6k2^tm1Dlin	involves: 129X1/SvJ * Black Swiss * C57BL/6	MGI:4354098

Genotype
MGI:4354098

hm1

• Allelic Composition: Ip6k2^tm1Dlin/Ip6k2^tm1Dlin
• Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased mortality induced by ionizing radiation ( J:151345 )

• median survival after treatment with 8 Gy TBI is 17 days compared with 10.5 in similarly treated wild-type mice

• unlike in wild-type mice, long-term survival following treatment with 8 Gy is 12.5%

increased susceptibility to xenobiotic induced morbidity/mortality ( J:151345 )

• after 30 weeks of 4-nitroquinoline 1-oxide (4-NQO) exposure, no mice survive compared to 75% of similarly treated wild-type mice

cellular

abnormal cell death ( J:151345 )

• fibroblasts exhibit enhanced survival compared with wild-type cells

increased fibroblast proliferation ( J:151345 )

• fibroblasts are resistant to the growth-suppressive effect of IFN-beta unlike wild-type cells

• fibroblasts exhibit increased colony-forming units compared with wild-type cells

abnormal double-strand DNA break repair ( J:151345 )

• radiation treated fibroblasts exhibit increased double-strand break repair compared with similarly treated wild-type mice

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:151345 )

• radiation treated fibroblasts exhibit increased double-strand break repair compared with similarly treated wild-type mice

decreased mortality induced by ionizing radiation ( J:151345 )

• median survival after treatment with 8 Gy TBI is 17 days compared with 10.5 in similarly treated wild-type mice

• unlike in wild-type mice, long-term survival following treatment with 8 Gy is 12.5%

increased susceptibility to xenobiotic induced morbidity/mortality ( J:151345 )

• after 30 weeks of 4-nitroquinoline 1-oxide (4-NQO) exposure, no mice survive compared to 75% of similarly treated wild-type mice

increased incidence of tumors by chemical induction ( J:151345 )

• 100% of 4-NQO-treated mice develop carcinoma in the esophagus, oral cavity, or stomach compared with 25% of similarly treated wild-type mice that develop neoplastic lesions in these areas

• epithelial cell invasion into the muscularis is 4-fold more common in 4-NQO-treated mice than in similarly treated wild-type mice

• 4-NQO-treated mice exhibit vascular invasion unlike in similarly treated wild-type mice

digestive/alimentary system

esophagus hyperplasia ( J:151345 )

• 4-NQO-treated mice develop mucosal hyperplasia and hyperkeratosis and, when advanced, distortion and partial obstruction of the lumen unlike in wild-type mice

neoplasm

increased incidence of tumors by chemical induction ( J:151345 )

• 100% of 4-NQO-treated mice develop carcinoma in the esophagus, oral cavity, or stomach compared with 25% of similarly treated wild-type mice that develop neoplastic lesions in these areas

• epithelial cell invasion into the muscularis is 4-fold more common in 4-NQO-treated mice than in similarly treated wild-type mice

• 4-NQO-treated mice exhibit vascular invasion unlike in similarly treated wild-type mice

growth/size/body

esophagus hyperplasia ( J:151345 )

• 4-NQO-treated mice develop mucosal hyperplasia and hyperkeratosis and, when advanced, distortion and partial obstruction of the lumen unlike in wild-type mice