All Phenotypes Mir96<Dmdo> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir96^Dmdo/Mir96^Dmdo	C3HeB/FeJ-Mir96^Dmdo	MGI:4354115
ht2	Mir96^Dmdo/Mir96⁺	C3HeB/FeJ-Mir96^Dmdo	MGI:4354117

Allelic Composition	Mir96^Dmdo/Mir96^Dmdo
Genetic Background	C3HeB/FeJ-Mir96^Dmdo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir96^Dmdo mutation (1 available); any Mir96 mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

decreased cochlear hair cell number ( J:151354 )

• at 4 to 6 weeks, very few hair cells remain

abnormal cochlear hair cell stereociliary bundle morphology ( J:151354 )

• mice exhibit irregular bundles and persistent clusters of ectopic stereocilia

cochlear hair cell degeneration ( J:151354 )

• by P7

absent cochlear nerve compound action potential ( J:151354 )

• at 4 weeks

deafness ( J:151354 )

behavior/neurological

absent pinna reflex ( J:151354 )

head bobbing ( J:151354 )

abnormal gait ( J:151354 )

• mice exhibit a staggering, circling gait

circling ( J:151354 )

nervous system

decreased cochlear hair cell number ( J:151354 )

• at 4 to 6 weeks, very few hair cells remain

abnormal cochlear hair cell stereociliary bundle morphology ( J:151354 )

• mice exhibit irregular bundles and persistent clusters of ectopic stereocilia

cochlear hair cell degeneration ( J:151354 )

• by P7

absent cochlear nerve compound action potential ( J:151354 )

• at 4 weeks

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal cochlear hair cell stereociliary bundle morphology ( J:151354 )

• outer hair cell bundles for loose U-shaped bundles rather than the precise V shape found in wild-type mice

• inner hair cell bundles are smaller and more widely separated than in wild-type mice

cochlear hair cell degeneration ( J:151354 )

• at 4 weeks

cochlear outer hair cell degeneration ( J:151354 )

• mice exhibit degeneration of outer hair cells in the middle and basal turns unlike in wild-type mice

• however, most inner hair cells remain intact

fused vestibular hair cell stereocilia ( J:151354 )

• at 4 weeks

decreased cochlear nerve compound action potential ( J:151354 )

• the threshold of compound action potentials is raised by about 60 dB compared to in wild-type mice

impaired hearing ( J:151354 )

behavior/neurological

abnormal pinna reflex ( J:151354 )

• mice exhibit a progressive lose of Preyer reflex between 4 and 6 weeks

nervous system

abnormal cochlear hair cell stereociliary bundle morphology ( J:151354 )

• outer hair cell bundles for loose U-shaped bundles rather than the precise V shape found in wild-type mice

• inner hair cell bundles are smaller and more widely separated than in wild-type mice

cochlear hair cell degeneration ( J:151354 )

• at 4 weeks

cochlear outer hair cell degeneration ( J:151354 )

• mice exhibit degeneration of outer hair cells in the middle and basal turns unlike in wild-type mice

• however, most inner hair cells remain intact

fused vestibular hair cell stereocilia ( J:151354 )

• at 4 weeks

decreased cochlear nerve compound action potential ( J:151354 )

• the threshold of compound action potentials is raised by about 60 dB compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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