Phenotypes associated with this allele

• Allele Symbol: Pax6^tm1Ued
• Allele Name: targeted mutation 1, University of Edinburgh
• Allele ID: MGI:4354122
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pax6^tm1Ued/Pax6^tm1Ued	involves: 129P2/OlaHsd * ICR	MGI:4354134
cn2	Pax6^tm1Ued/Pax6^tm1Ued Tg(Six3-cre)69Frty/0	involves: 129P2/OlaHsd * ICR	MGI:4354135

Genotype
MGI:4354134

hm1

• Allelic Composition: Pax6^tm1Ued/Pax6^tm1Ued
• Genetic Background: involves: 129P2/OlaHsd * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:151427 )

• mice are viable, fertile, and indistinguishable from wild-type mice

Genotype
MGI:4354135

cn2

• Allelic Composition: Pax6^tm1Ued/Pax6^tm1Ued; Tg(Six3-cre)69Frty/0
• Genetic Background: involves: 129P2/OlaHsd * ICR

nervous system

abnormal telencephalon development ( J:151427 )

• thalamocortical axonal development is disrupted compared to in wild-type mice

• at E14.5, the cell-sparse zone spanning the diencephalic-telencephalic border appears disorganized and only a narrow cell-sparse shaft extended across the ventral telencephalon unlike in wild-type mice

• at E14.5, an abnormally thin bundle of thalamocortical axons cross the ventral telencephalon with much of the bundle of axons descending through the diencephalon appearing to end at the diencephalic-telencephalic border unlike in wild-type mice

• at E14.5, a small number of axons leave the internal capsule along it's length to grow in a ventral direction unlike in wild-type mice

• at E16.5, the internal capsule appears abnormally narrow and reduced in size compared to in wild-type mice

• at E16.5, diI injections label a bifurcated tract in which some axons course ventrally in the direction of the hypothalamus unlike in wild-type mice

• unlike in wild-type mice, many thalamic axons fail to navigate normal from the diencephalic-telencephalic border to the internal capsule and fail to exit in a ventral direction

• at E16.5, some descending corticofugal axons from the visual cortex become misrouted unlike in wild-type mice

abnormal brain internal capsule morphology ( J:151427 )

• at E16.5, the internal capsule appears abnormally narrow and reduced in size compared to in wild-type mice