Phenotypes associated with this allele

• Allele Symbol: Fgf21^tm1.1Djm
• Allele Name: targeted mutation 1.1, David J Mangelsdorf
• Allele ID: MGI:4354163
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf21^tm1.1Djm/Fgf21^tm1.1Djm	involves: 129S6/SvEvTac * C57BL/6	MGI:4354176

Genotype
MGI:4354176

hm1

• Allelic Composition: Fgf21^tm1.1Djm/Fgf21^tm1.1Djm
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:150831 )

• in fasted mice

hypoglycemia ( J:150831 )

decreased circulating ketone body level ( J:150831 )

• in fed mice

decreased oxygen consumption ( J:150831 )

• in fasted mice

abnormal gluconeogenesis ( J:150831 )

• in response to fasting, mice fail to display increased gluconeogenesis in the liver as in wild-type mice

decreased physiological sensitivity to xenobiotic ( J:150831 )

• treatment with octanoate only increased plasma beta-hydroxybutyrate concentrations by 20% compared to the doubling observed in similarly treated wild-type mice