All Phenotypes Tg(Apoe-Fgf21)1Sakl MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Klb^tm1.2Sakl/Klb⁺ Tg(Apoe-Fgf21)1Sakl/0	involves: 129 * 129S4/SvJaeSor * C57BL/6	MGI:5446169
cx2	Klb^tm1.2Sakl/Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl/0	involves: 129 * 129S4/SvJaeSor * C57BL/6	MGI:5446170
tg3	Tg(Apoe-Fgf21)1Sakl/0	Not Specified	MGI:4354175

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:189018 )

• in mice fed a high fat diet

decreased circulating insulin level ( J:189018 )

• in mice fed a high fat diet

decreased circulating leptin level ( J:189018 )

• in mice fed a high fat diet

decreased circulating cholesterol level ( J:189018 )

• in mice fed a high fat diet

decreased circulating free fatty acids level ( J:189018 )

• in mice fed a high fat diet

decreased circulating triglyceride level ( J:189018 )

• in mice fed a high fat diet

improved glucose tolerance ( J:189018 )

• in mice fed a high fat diet

increased insulin sensitivity ( J:189018 )

• in mice fed a high fat diet

increased circulating adiponectin level ( J:189018 )

• in mice fed a high fat diet

decreased liver cholesterol level ( J:189018 )

• in mice fed a high fat diet

decreased liver triglyceride level ( J:189018 )

• in mice fed a high fat diet

skeleton

short tibia ( J:189018 )

• compared with Klb^tm1.2Sakl heterozygotes

adipose tissue

decreased percent body fat/body weight ( J:189018 )

• in mice fed standard chow or a high fat diet compared with Klb^tm1.2Sakl heterozygotes

growth/size/body

increased lean body mass ( J:189018 )

• in mice fed standard chow or a high fat diet compared with Klb^tm1.2Sakl heterozygotes

decreased body weight ( J:189018 )

• compared with Klb^tm1.2Sakl heterozygotes

decreased susceptibility to weight gain ( J:189018 )

• in mice fed a high fat diet

behavior/neurological

abnormal eating behavior ( J:189018 )

• compared with Klb^tm1.2Sakl heterozygotes

liver/biliary system

decreased liver cholesterol level ( J:189018 )

• in mice fed a high fat diet

decreased liver triglyceride level ( J:189018 )

• in mice fed a high fat diet

decreased liver weight ( J:189018 )

• in mice fed a high fat diet

decreased susceptibility to diet-induced hepatic steatosis ( J:189018 )

• mice fed a high fat diet do not develop a pale liver and have less lipid droplets compared to Klb^tm1.2Sakl heterozygotes

limbs/digits/tail

short tibia ( J:189018 )

• compared with Klb^tm1.2Sakl heterozygotes

Allelic Composition	Klb^tm1.2Sakl/Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl/0
Genetic Background	involves: 129 * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klb^tm1.2Sakl mutation (0 available); any Klb mutation (58 available)
Tg(Apoe-Fgf21)1Sakl mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal blood homeostasis ( J:189018 )

• mice fed a high fat diet fail to exhibit changes in circulating triglyceride, cholesterol, leptin, adiponectin, insulin and glucose observed in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

decreased circulating free fatty acids level ( J:189018 )

• in mice fed a high fat diet but not as severe as in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

abnormal glucose homeostasis ( J:189018 )

• mice fed a high fat diet fail to exhibit improved glucose tolerance and insulin sensitivity observed in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

growth/size/body

abnormal lean body mass ( J:189018 )

• mice fail to exhibit altered body composition observed in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

decreased body weight ( J:189018 )

• not as severe as in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

adipose tissue

abnormal percent body fat/body weight ( J:189018 )

• mice fail to exhibit altered body composition observed in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

behavior/neurological

abnormal food intake ( J:189018 )

• mice fail to exhibit an increase in food intake observed in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

limbs/digits/tail

short tibia ( J:189018 )

• as in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

liver/biliary system

abnormal liver morphology ( J:189018 )

• mice fed a high fat diet fail to exhibit a decrease in liver weight and hepatic triglyceride and cholesterol levels observed in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

skeleton

short tibia ( J:189018 )

• as in Klb^tm1.2Sakl Tg(Apoe-Fgf21)1Sakl heterozygotes

Allelic Composition	Tg(Apoe-Fgf21)1Sakl/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Apoe-Fgf21)1Sakl mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased oxygen consumption ( J:150831 )

• hepatic oxygen consumption is increased in fasting mice compared with wild-type mice

• however, hepatic oxygen consumption under fed condition is normal

abnormal gluconeogenesis ( J:150831 )

• under fed conditions, liver gluconeogenesis is increased 60% compared to in similarly treated wild-type mice

• however, liver gluconeogenesis does not increase further under fasting conditions

increased liver glycogen level ( J:150831 )

• liver glycogen content increased 50% compared to in wild-type mice

liver/biliary system

increased liver glycogen level ( J:150831 )

• liver glycogen content increased 50% compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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