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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(APOE-MBOAT4)1Jagu
transgene insertion 1, Jesus A Gutierrez
MGI:4354173
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(APOE-GHRL)1Jagu/0
Tg(APOE-MBOAT4)1Jagu/0
Not Specified MGI:4354198


Genotype
MGI:4354198
cx1
Allelic
Composition
Tg(APOE-GHRL)1Jagu/0
Tg(APOE-MBOAT4)1Jagu/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• fat mass is significantly higher than controls 4 weeks after being fed a diet high in medium-chain triglycerides

growth/size/body
• body weight is significantly higher than controls 4 weeks after being fed a diet high in medium-chain triglycerides

homeostasis/metabolism
• mice contain in circulation des-acyl and acyl forms of human ghrelin
• when fed a diet high in medium-chain triglycerides, ghrelin levels are over 100-fold higher than endogenous with acyl-activation forms also significantly elevated
• mice fed a diet high in medium-chain triglycerides have less energy expenditure than diet-matched controls
• gene expression analysis suggests decreased mitochondrial fat oxidation in skeletal muscle





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory