Phenotypes associated with this allele

• Allele Symbol: Tg(Tyr-BRAF*V600E)476Fgh
• Allele Name: transgene insertion 476, Frank G Haluska
• Allele ID: MGI:4354193
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(Tyr-BRAF*V600E)476Fgh/0	involves: 129/Sv * C57BL/6J * CBA * SJL	MGI:4354208
tg2	Tg(Tyr-BRAF*V600E)476Fgh/0	involves: C57BL/6J * CBA	MGI:4354206

Genotype
MGI:4354208

cx1

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp; Tg(Tyr-BRAF*V600E)476Fgh/0
• Genetic Background: involves: 129/Sv * C57BL/6J * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:151455 )

• survival is less than in Tg(Tyr-BRAF*V600E)470Fgh mice

neoplasm

increased melanoma incidence ( J:151455 )

• mice develop increased incidence of melanomas with reduced latency and decreased lifespan compared to mice with Tg(Tyr-BRAF*V600E)476Fgh

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
melanoma		DOID:1909		J:151455

Genotype
MGI:4354206

tg2

• Allelic Composition: Tg(Tyr-BRAF*V600E)476Fgh/0
• Genetic Background: involves: C57BL/6J * CBA

mortality/aging

premature death ( J:151455 )

• median survival is 595 days

neoplasm

increased malignant tumor incidence ( J:151455 )

• mice rarely develop melanomas

pigmentation

abnormal melanocyte morphology ( J:151455 )

• mice develop benign melanocyte hyperplasia showing large nests of epithelioid cells generally located in the deep dermis and subcutis