Analysis Tools
nervous system
| N |
• desensitization and internalization of opioid receptors after met-enkephalin treatment is similar to that in controls
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Allele Symbol Allele Name Allele ID |
Tg(Th-Oprm1)4Jtw transgene insertion 4, John T Williams MGI:4354389 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• desensitization and internalization of opioid receptors after met-enkephalin treatment is similar to that in controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• maximum hyperpolarization of neurons induced by met-enkephalin (ME) is similar to that seen in wild-type and transgenic wild-type opioid receptor mutant animals; the EC50 for ME is 50% greater than the transgene-only mutants
• desensitization by ME and recovery of desensitization of receptors is similar to wild-type and transgene-only controls
• desensitization and internalization of the mu-opioid receptor (MOR) in response to various MOR agonists is not different in mutants and controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• activation of the mu-opioid receptor (MOR) by met-enkephalin (ME) induces a hyperpolarization which desensitizes acutely to the same extent as the endogenous receptor in wild-type mice; a 7-fold decrease in the EC50 for ME is observed with the increased receptor expression seen in mutants
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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