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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cbltm1Soga
targeted mutation 1, Seishi Ogawa
MGI:4354652
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cbltm1Soga/Cbltm1Soga Not Specified MGI:4354765
cx2
 		Cbltm1Soga/Cbltm1Soga
Tg(Tec-BCR/ABL1)5Hhi/0 		involves: C57BL/6 * DBA/2 MGI:4354766
cx3
 		Cbltm1Soga/Cbl+
Tg(Tec-BCR/ABL1)5Hhi/0 		involves: C57BL/6 * DBA/2 MGI:4354767


Genotype
MGI:4354765
hm1
Allelic
Composition		 Cbltm1Soga/Cbltm1Soga
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbltm1Soga mutation (0 available); any Cbl mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system
increased hematopoietic stem cell number ( J:151543 )
• as determined by colony formation from bone marrow cells in methycellulose culture

growth/size/body
enlarged spleen ( J:151543 )




Genotype
MGI:4354766
cx2
Allelic
Composition		 Cbltm1Soga/Cbltm1Soga
Tg(Tec-BCR/ABL1)5Hhi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbltm1Soga mutation (0 available); any Cbl mutation (59 available)
Tg(Tec-BCR/ABL1)5Hhi mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:151543 )
• all mice die by 41 weeks after birth with accelerated blast crisis compared to in Tg(BCR/ABL1)5Hhi mice

immune system
enlarged lymph nodes ( J:151543 )
• mice exhibit enlarged lymph nodes during blastic crisis with massive infiltrates of immature leukemic blasts




Genotype
MGI:4354767
cx3
Allelic
Composition		 Cbltm1Soga/Cbl+
Tg(Tec-BCR/ABL1)5Hhi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbltm1Soga mutation (0 available); any Cbl mutation (59 available)
Tg(Tec-BCR/ABL1)5Hhi mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:151543 )
• mice die prematurely with accelerated blast crisis compared to in Tg(BCR/ABL1)5Hhi mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory