Phenotypes associated with this allele

• Allele Symbol: Klf2^tm2Ling
• Allele Name: targeted mutation 2, Jerry B Lingrel
• Allele ID: MGI:4355063
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Klf2^tm2Ling/Klf2^tm2Ling Lyz2^tm1(cre)Ifo/0	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:5829819
cn2	Klf2^tm2Ling/Klf2^tm2Ling Tg(Cd4-cre)1Cwi/?	involves: 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:4355162

Genotype
MGI:5829819

cn1

• Allelic Composition: Klf2^tm2Ling/Klf2^tm2Ling; Lyz2^tm1(cre)Ifo/0
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased Ly6C low monocyte number ( J:239509 )

• decrease in Ly6^low blood and bone marrow monocytes as compared to controls

immune system

decreased Ly6C low monocyte number ( J:239509 )

• decrease in Ly6^low blood and bone marrow monocytes as compared to controls

Genotype
MGI:4355162

cn2

• Allelic Composition: Klf2^tm2Ling/Klf2^tm2Ling; Tg(Cd4-cre)1Cwi/?
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

hematopoietic system

abnormal T cell differentiation ( J:151604 )

• single positive (SP) alpha-beta thymocytes express high levels of CXCR3

• CD8⁺ SP thymocytes express higher levels of CXCR3 than CD4⁺ SP thymocytes

• mixed bone marrow chimera experiments suggest CXCR3 expression is extrinsic to the thymocytes

• SP thymocytes secrete high levels of IL-4

• mixed bone marrow chimera experiments also demonstrate that a cell intrinsic defect in emigration of mutant single positive thymocytes from the thymus

decreased T cell number ( J:151604 )

• mice have severe T cell lymphopenia

increased single-positive T cell number ( J:151604 )

• single positive thymocytes are increased

increased IgE level ( J:151604 )

• IgE levels are increased 33-fold

increased IgG1 level ( J:151604 )

• IgG1 levels are modestly increased

immune system

abnormal T cell differentiation ( J:151604 )

• single positive (SP) alpha-beta thymocytes express high levels of CXCR3

• CD8⁺ SP thymocytes express higher levels of CXCR3 than CD4⁺ SP thymocytes

• mixed bone marrow chimera experiments suggest CXCR3 expression is extrinsic to the thymocytes

• SP thymocytes secrete high levels of IL-4

• mixed bone marrow chimera experiments also demonstrate that a cell intrinsic defect in emigration of mutant single positive thymocytes from the thymus

decreased T cell number ( J:151604 )

• mice have severe T cell lymphopenia

increased single-positive T cell number ( J:151604 )

• single positive thymocytes are increased

increased IgE level ( J:151604 )

• IgE levels are increased 33-fold

increased IgG1 level ( J:151604 )

• IgG1 levels are modestly increased

increased interleukin-4 secretion ( J:151604 )

• single-positive thymocytes produce about four-fold more IL-4 compared to controls