Phenotypes associated with this allele

• Allele Symbol: Decr1^tm1Jkh
• Allele Name: targeted mutation 1, J Kalervo Hiltunen
• Allele ID: MGI:4355415
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Decr1^tm1Jkh/Decr1^tm1Jkh	B6.129X1-Decr1^tm1Jkh	MGI:4355424

Genotype
MGI:4355424

hm1

• Allelic Composition: Decr1^tm1Jkh/Decr1^tm1Jkh
• Genetic Background: B6.129X1-Decr1^tm1Jkh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Fasted Decr1^tm1Jkh/Decr1^tm1Jkh mice show accumulation of lipids in the liver

growth/size/body

increased liver weight ( J:151622 )

homeostasis/metabolism

impaired adaptive thermogenesis ( J:151622 )

• after exposure to 4 degrees Celsius after a 20 hours fast, mice exhibit severe cold intolerance compared with similarly treated wild-type mice

• 2 hours after cold exposure, fasted mice lose their shivering response and become lethargy unlike in similarly treated wild-type mice

• however, normally fed mice exposed to cold conditions exhibit a normal response

• cold exposed mice exhibit decreased heat production compared with similarly treated wild-type mice

decreased circulating glucose level ( J:151622 )

• after a 24 hour fast, mice exhibit a reduction in serum glucose levels unlike in similarly treated wild-type mice

• longer fasts produce greater decreases in serum glucose compared to in similarly treated wild-type mice

• mice exhibit an accelerated hypoglycemic response to fasting compared to in similarly treated wild-type mice

• following fasting and cold exposure, mice exhibit decreased serum glucose levels compared with similarly treated wild-type mice

increased fatty acids level ( J:151622 )

• after fasting, serum levels of non-esterified fatty acids is increased compared to in similarly treated wild-type mice

• after fasting, mice exhibit a 108% increase in the liver compared to a 29% increase in similarly treated wild-type mice

• following fasting and cold exposure, mice exhibit increased non-esterified fatty acid levels compared with similarly treated wild-type mice

liver/biliary system

increased liver weight ( J:151622 )

microvesicular hepatic steatosis ( J:151622 )

• unlike in wild-type mice, livers contain hepatocytes with a foamy appearance and centralized nuclei in the periportal and midzonal regions characteristic of microvesicular steatosis

pale liver ( J:151622 )

behavior/neurological

lethargy ( J:151622 )

• 2 hours after cold exposure, fasted mice lose their shivering response and become lethargy unlike in similarly treated wild-type mice

tremors ( J:151622 )

• 2 hours after cold exposure, fasted mice lose their shivering response and become lethargy unlike in similarly treated wild-type mice

decreased locomotor activity ( J:151622 )

• during fasting, mice exhibit decreased activity compared with similarly treated wild-type mice especially during the dark phase

• fasted and cold exposed mice exhibit a decrease in activity close to zero unlike similarly treated wild-type mice