Phenotypes associated with this allele

• Allele Symbol: Fancm^tm1.1Htr
• Allele Name: targeted mutation 1.1, Hein Te Riele
• Allele ID: MGI:4355560
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fancm^tm1.1Htr/Fancm^tm1.1Htr	involves: C57BL/6 * FVB	MGI:4355568
ht2	Fancm^tm1.1Htr/Fancm^+	involves: C57BL/6 * FVB	MGI:4355567

Genotype
MGI:4355568

hm1

• Allelic Composition: Fancm^tm1.1Htr/Fancm^tm1.1Htr
• Genetic Background: involves: C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:151714 )

• mice survive 573 days compared to wild-type mice which survive for more than 730 days

liver/biliary system

increased hepatoma incidence ( J:151714 )

• in 3 of 21 mice

reproductive system

azoospermia ( J:151714 )

♂ • in some seminiferous tubules

abnormal spermatogonia morphology ( J:151714 )

♂ • absent in some seminiferous tubules

abnormal ovary morphology ( J:151714 )

♀ • the cortex is depleted of primary follicles unlike in wild-type mice

decreased mature ovarian follicle number ( J:151714 )

♀

abnormal seminiferous tubule morphology ( J:151714 )

♂ • some seminiferous tubules lack spermatogonia and contain no sperm unlike in wild-type mice

increased Leydig cell number ( J:151714 )

♂

small testis ( J:151714 )

♂

transmission ratio distortion ( J:151714 )

• fewer than expected female are produced

neoplasm

increased tumor incidence ( J:151714 )

• 52% of mice develop tumors (including lymphomas, hepatoma, histiocytic sarcoma, lung carcinoma, and other tumors) compared to 14% of wild-type mice

• 3 of 21 mice develop arteritis nodosa compared to 1 of 57 wild-type mice

increased hepatoma incidence ( J:151714 )

• in 3 of 21 mice

cellular

azoospermia ( J:151714 )

♂ • in some seminiferous tubules

abnormal spermatogonia morphology ( J:151714 )

♂ • absent in some seminiferous tubules

elevated level of mitotic sister chromatid exchange ( J:151714 )

• in mouse embryonic fibroblasts

hematopoietic system

hematopoietic system phenotype ( J:151714 )

N • mice exhibit normal numbers of hematopoietic stems cells

endocrine/exocrine glands

abnormal ovary morphology ( J:151714 )

♀ • the cortex is depleted of primary follicles unlike in wild-type mice

decreased mature ovarian follicle number ( J:151714 )

♀

abnormal seminiferous tubule morphology ( J:151714 )

♂ • some seminiferous tubules lack spermatogonia and contain no sperm unlike in wild-type mice

increased Leydig cell number ( J:151714 )

♂

small testis ( J:151714 )

♂

Genotype
MGI:4355567

ht2

• Allelic Composition: Fancm^tm1.1Htr/Fancm⁺
• Genetic Background: involves: C57BL/6 * FVB

mortality/aging

premature death ( J:151714 )

• mice survive 693 days compared to wild-type mice which survive for more than 730 days

neoplasm

increased tumor incidence ( J:151714 )

• 39% of mice develop tumors (including lymphomas, hepatoma, histiocytic sarcoma, lung carcinoma, and other tumors) compared to 14% of wild-type mice