About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ifnb1tm2.1Lien
targeted mutation 2.1, Stefan Lienenklaus
MGI:4355683
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ifnb1tm2.1Lien/Ifnb1tm2.1Lien
Tyrc-2J/Tyrc-2J
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:5007898
cn2
 		Ifnb1tm2.1Lien/Ifnb1tm2.1Lien
Tg(Itgax-cre)1-1Reiz/0
Tyrc-2J/Tyrc-2J 		involves: C57BL/6 * CBA MGI:5007897
cx3
 		Ifnb1tm2.1Lien/Ifnb1tm2.1Lien
Tyrc-2J/Tyrc-2J 		involves: C57BL/6 MGI:5007896


Genotype
MGI:5007898
cn1
Allelic
Composition		 Ifnb1tm2.1Lien/Ifnb1tm2.1Lien
Tyrc-2J/Tyrc-2J
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnb1tm2.1Lien mutation (0 available); any Ifnb1 mutation (21 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Tyrc-2J mutation (26 available); any Tyr mutation (379 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased circulating interferon-alpha level ( J:172226 )
• following L. monocytogenes infection
decreased circulating interferon-beta level ( J:172226 )
• following L. monocytogenes infection
decreased susceptibility to bacterial infection ( J:172226 )
• following L. monocytogenes infection, mice exhibit decreased circulating interferon-alpha and -beta and decreased bacterial numbers in the spleen and liver compared with wild-type mice

homeostasis/metabolism
decreased circulating interferon-alpha level ( J:172226 )
• following L. monocytogenes infection
decreased circulating interferon-beta level ( J:172226 )
• following L. monocytogenes infection




Genotype
MGI:5007897
cn2
Allelic
Composition		 Ifnb1tm2.1Lien/Ifnb1tm2.1Lien
Tg(Itgax-cre)1-1Reiz/0
Tyrc-2J/Tyrc-2J
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnb1tm2.1Lien mutation (0 available); any Ifnb1 mutation (21 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
Tyrc-2J mutation (26 available); any Tyr mutation (379 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:172226 )
N
• mice exhibit normal response to L. monocytogenes infection




Genotype
MGI:5007896
cx3
Allelic
Composition		 Ifnb1tm2.1Lien/Ifnb1tm2.1Lien
Tyrc-2J/Tyrc-2J
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnb1tm2.1Lien mutation (0 available); any Ifnb1 mutation (21 available)
Tyrc-2J mutation (26 available); any Tyr mutation (379 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:172226 )
N
• mice exhibit normal response to L. monocytogenes infection




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory