Phenotypes associated with this allele

• Allele Symbol: Trex2^tm1.2Coso
• Allele Name: targeted mutation 1.2, Concepcio Soler
• Allele ID: MGI:4355746
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trex2^tm1.2Coso/Trex2^tm1.2Coso	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1	MGI:4355749
ot2	Trex2^tm1.2Coso/Y	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1	MGI:4355750

Genotype
MGI:4355749

hm1

• Allelic Composition: Trex2^tm1.2Coso/Trex2^tm1.2Coso
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:151766 )

♀ • application of DMBA alone or followed by TPA produces more and larger skin tumors than in similarly treated wild-type mice

♀ • by week 7, 39% of DMBA-treated mice develop skin tumors compared with 6% of similarly treated wild-type mice

♀ • by week 9, 88% of DMBA-treated mice develop skin tumors compared with 60% of similarly treated wild-type mice

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:151766 )

♀ • application of DMBA alone or followed by TPA produces more and larger skin tumors than in similarly treated wild-type mice

♀ • by week 7, 39% of DMBA-treated mice develop skin tumors compared with 6% of similarly treated wild-type mice

♀ • by week 9, 88% of DMBA-treated mice develop skin tumors compared with 60% of similarly treated wild-type mice

integument

abnormal skin physiology ( J:151766 )

♀ • apoptosis in the epidermis of DMBA or DMBA and TPA treated mice is decreased compared to in similarly treated wild-type mice

abnormal keratinocyte physiology ( J:151766 )

♀ • keratinocytes are more resistant than wild-type cells to DMBA-induced genotoxicity

decreased keratinocyte apoptosis ( J:151766 )

♀ • in DMBA-treated mice

cellular

decreased keratinocyte apoptosis ( J:151766 )

♀ • in DMBA-treated mice

Genotype
MGI:4355750

ot2

• Allelic Composition: Trex2^tm1.2Coso/Y
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

neoplasm

increased incidence of tumors by chemical induction ( J:151766 )

♂ • application of DMBA alone or followed by TPA produces more and larger skin tumors than in similarly treated wild-type mice

♂ • by week 7, 39% of DMBA-treated mice develop skin tumors compared with 6% of similarly treated wild-type mice

♂ • by week 9, 88% of DMBA-treated mice develop skin tumors compared with 60% of similarly treated wild-type mice

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:151766 )

♂ • application of DMBA alone or followed by TPA produces more and larger skin tumors than in similarly treated wild-type mice

♂ • by week 7, 39% of DMBA-treated mice develop skin tumors compared with 6% of similarly treated wild-type mice

♂ • by week 9, 88% of DMBA-treated mice develop skin tumors compared with 60% of similarly treated wild-type mice

integument

abnormal skin physiology ( J:151766 )

♂ • apoptosis in the epidermis of DMBA or DMBA and TPA treated mice is decreased compared to in similarly treated wild-type mice

abnormal keratinocyte physiology ( J:151766 )

♂ • keratinocytes are more resistant than wild-type cells to DMBA-induced genotoxicity

decreased keratinocyte apoptosis ( J:151766 )

♂ • in DMBA-treated mice

cellular

decreased keratinocyte apoptosis ( J:151766 )

♂ • in DMBA-treated mice