Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr183tm1.2Rbr mutation
(0 available);
any
Gpr183 mutation
(25 available)
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immune system
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• in response to sheep red blood cell immunization, mice produce fewer IgG1+B220lo extrafollicular plasma cells unlike in similarly treated wild-type mice
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• naive B cells transferred into CD45.1 congenic wild-type mice fail to distribute evenly within splenic and lymph node B cell areas; instead, they accumulate in the center of B cell follicles and congregate around germinal centers
• however, chemotactic response of naive polyclonal B cells to lymph chemokine is normal
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hematopoietic system
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• in response to sheep red blood cell immunization, mice produce fewer IgG1+B220lo extrafollicular plasma cells unlike in similarly treated wild-type mice
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• naive B cells transferred into CD45.1 congenic wild-type mice fail to distribute evenly within splenic and lymph node B cell areas; instead, they accumulate in the center of B cell follicles and congregate around germinal centers
• however, chemotactic response of naive polyclonal B cells to lymph chemokine is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr183tm1.2Rbr mutation
(0 available);
any
Gpr183 mutation
(25 available)
Ightm1Rbr mutation
(4 available);
any
Igh mutation
(44 available)
Tg(IgkHyHEL10)1Rbr mutation
(4 available)
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immune system
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• 5 days following immunization with sheep red blood cell, B cells are observed at reduced frequency in the spleen compared to in similarly treated Ightm1Rbr/Ightm1Rbr Tg(IgkHyHEL10)1Rbr mice
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• after activation with HEL-conjugated sheep red blood cell, fewer B cells acquired plasmablasts phenotype compared to in similarly treated Ightm1Rbr/Ightm1Rbr Tg(IgkHyHEL10)1Rbr mice
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• B cells fail to display a robust extrafollicular plasmablast response due to reduced migration of responding B cells to the bridging channel and red pulp arrears unlike in Ightm1Rbr/Ightm1Rbr Tg(IgkHyHEL10)1Rbr mice
• however, expression of chemokine receptors is normal
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• 1 day after activation with HEL-conjugated sheep red blood cell, B cells do not distribute uniformly along the B-T boundary in the spleen and often migrate deep into T cell areas unlike in similarly treated Ightm1Rbr/Ightm1Rbr Tg(IgkHyHEL10)1Rbr mice
• 3 days after activation with HEL-conjugated sheep red blood cell, B cells fail to move to the poles of the B cell follicles proximal to bridging and interfollicular regions and instead remain localized in central follicular areas proximal to the T cell zone unlike in similarly treated Ightm1Rbr/Ightm1Rbr Tg(IgkHyHEL10)1Rbr mice
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• following immunization with sheep red blood cell, B cell proliferation is delayed compared to in similarly treated Ightm1Rbr/Ightm1Rbr Tg(IgkHyHEL10)1Rbr mice
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• following activation with HEL-conjugated sheep red blood cell, anti-HEL IgG1 levels are reduced to 10% to 20% of that in similarly treated Ightm1Rbr/Ightm1Rbr Tg(IgkHyHEL10)1Rbr mice
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• following activation with HEL-conjugated sheep red blood cell, anti-HEL IgM levels are reduced to 10% to 20% of that in similarly treated Ightm1Rbr/Ightm1Rbr Tg(IgkHyHEL10)1Rbr mice
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hematopoietic system
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• 5 days following immunization with sheep red blood cell, B cells are observed at reduced frequency in the spleen compared to in similarly treated Ightm1Rbr/Ightm1Rbr Tg(IgkHyHEL10)1Rbr mice
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• after activation with HEL-conjugated sheep red blood cell, fewer B cells acquired plasmablasts phenotype compared to in similarly treated Ightm1Rbr/Ightm1Rbr Tg(IgkHyHEL10)1Rbr mice
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• B cells fail to display a robust extrafollicular plasmablast response due to reduced migration of responding B cells to the bridging channel and red pulp arrears unlike in Ightm1Rbr/Ightm1Rbr Tg(IgkHyHEL10)1Rbr mice
• however, expression of chemokine receptors is normal
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• 1 day after activation with HEL-conjugated sheep red blood cell, B cells do not distribute uniformly along the B-T boundary in the spleen and often migrate deep into T cell areas unlike in similarly treated Ightm1Rbr/Ightm1Rbr Tg(IgkHyHEL10)1Rbr mice
• 3 days after activation with HEL-conjugated sheep red blood cell, B cells fail to move to the poles of the B cell follicles proximal to bridging and interfollicular regions and instead remain localized in central follicular areas proximal to the T cell zone unlike in similarly treated Ightm1Rbr/Ightm1Rbr Tg(IgkHyHEL10)1Rbr mice
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• following immunization with sheep red blood cell, B cell proliferation is delayed compared to in similarly treated Ightm1Rbr/Ightm1Rbr Tg(IgkHyHEL10)1Rbr mice
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• following activation with HEL-conjugated sheep red blood cell, anti-HEL IgG1 levels are reduced to 10% to 20% of that in similarly treated Ightm1Rbr/Ightm1Rbr Tg(IgkHyHEL10)1Rbr mice
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• following activation with HEL-conjugated sheep red blood cell, anti-HEL IgM levels are reduced to 10% to 20% of that in similarly treated Ightm1Rbr/Ightm1Rbr Tg(IgkHyHEL10)1Rbr mice
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cellular
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• 1 day after activation with HEL-conjugated sheep red blood cell, B cells do not distribute uniformly along the B-T boundary in the spleen and often migrate deep into T cell areas unlike in similarly treated Ightm1Rbr/Ightm1Rbr Tg(IgkHyHEL10)1Rbr mice
• 3 days after activation with HEL-conjugated sheep red blood cell, B cells fail to move to the poles of the B cell follicles proximal to bridging and interfollicular regions and instead remain localized in central follicular areas proximal to the T cell zone unlike in similarly treated Ightm1Rbr/Ightm1Rbr Tg(IgkHyHEL10)1Rbr mice
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• following immunization with sheep red blood cell, B cell proliferation is delayed compared to in similarly treated Ightm1Rbr/Ightm1Rbr Tg(IgkHyHEL10)1Rbr mice
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Analysis Tools