Analysis Tools
endocrine/exocrine glands
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• over time endocrine and exocrine components are replaced with abnormal ductal structures
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• as early as 3 weeks, mice develop enlarged and dilated ductal structures resembling budding cysts unlike in wild-type mice
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• with age, islets become disorganized
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• as early 7 weeks
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• mice develop pancreatic intraepithelial neoplasia and tumors reminiscent of human intraductal papillary mucinous neoplasm
• however, mice do not exhibit macroscopic evidence of invasive carcinoma
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• as early as 3 weeks, mice develop pancreatic intraepithelial neoplasias
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• as early 7 weeks, mice exhibit multifocal cystic lesions unlike wild-type mice
• all mice develop cysts that at 6 weeks occupy 50% of the pancreatic area unlike in wild-type mice
• cysts are composed of epithelial cells with cuboidal or cylindrical morphologies that form numerous papillary projections into the cysts
• papillary projections contain masses of small monomorphic cells with an endocrine morphology
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• as early as 3 weeks, mice develop acute inflammation of the pancreas unlike wild-type mice
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neoplasm
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• mice develop pancreatic intraepithelial neoplasia and tumors reminiscent of human intraductal papillary mucinous neoplasm
• however, mice do not exhibit macroscopic evidence of invasive carcinoma
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• as early as 3 weeks, mice develop pancreatic intraepithelial neoplasias
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immune system
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• as early as 3 weeks, mice develop acute inflammation of the pancreas unlike wild-type mice
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digestive/alimentary system
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• as early as 3 weeks, mice develop enlarged and dilated ductal structures resembling budding cysts unlike in wild-type mice
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growth/size/body
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• as early 7 weeks
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• as early 7 weeks, mice exhibit multifocal cystic lesions unlike wild-type mice
• all mice develop cysts that at 6 weeks occupy 50% of the pancreatic area unlike in wild-type mice
• cysts are composed of epithelial cells with cuboidal or cylindrical morphologies that form numerous papillary projections into the cysts
• papillary projections contain masses of small monomorphic cells with an endocrine morphology
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