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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cd1d1tm1.1Boes
targeted mutation 1.1, Marianne Boes
MGI:4355877
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cd1d1tm1.1Boes/Cd1d1tm1.1Boes involves: C57BL/6 MGI:4355883
cx2
Cd1d1tm1.1Boes/Cd1d1tm1.1Boes
Cd74tm1Doi/Cd74tm1Doi
involves: 129S2/SvPas * C57BL/6 MGI:4355888


Genotype
MGI:4355883
hm1
Allelic
Composition
Cd1d1tm1.1Boes/Cd1d1tm1.1Boes
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1.1Boes mutation (0 available); any Cd1d1 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Valpha14 invariant NKT cell displaya bias in their Vbeta repertoire, with an overrepresentation of Vbeta7
• thymic Valpha14 invariant NKT cells significantly remain in the earlier stages of development compared to controls
• these cells have increased expression of immature markers such as Slamf1 and CD69
• thymic Valpha14 invariant NKT cells at all stages of development in the thymus display increased rates of apoptosis compared to controls
• Valpha14 invariant NKT cell numbers are reduced 60% in the thymus and 80% in the liver and spleen
• Valpha14 invariant NKT cells have reduced expression of IL-2 and IL-4 when activated
• IFN-gamma secretion upon activation is similar to controls
• dendritic cells loaded with alphaGal-Cer are defective in activating wild-type Valpha14 invariant NKT cells
• Valpha14 invariant NKT cells have reduced expression of IL-2 and IL-4 when activated
• Valpha14 invariant NKT cells have reduced expression of IL-2 and IL-4 when activated

hematopoietic system
• these cells have increased expression of immature markers such as Slamf1 and CD69
• Valpha14 invariant NKT cell displaya bias in their Vbeta repertoire, with an overrepresentation of Vbeta7
• thymic Valpha14 invariant NKT cells significantly remain in the earlier stages of development compared to controls
• thymic Valpha14 invariant NKT cells at all stages of development in the thymus display increased rates of apoptosis compared to controls
• Valpha14 invariant NKT cell numbers are reduced 60% in the thymus and 80% in the liver and spleen
• Valpha14 invariant NKT cells have reduced expression of IL-2 and IL-4 when activated
• IFN-gamma secretion upon activation is similar to controls




Genotype
MGI:4355888
cx2
Allelic
Composition
Cd1d1tm1.1Boes/Cd1d1tm1.1Boes
Cd74tm1Doi/Cd74tm1Doi
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1.1Boes mutation (0 available); any Cd1d1 mutation (35 available)
Cd74tm1Doi mutation (1 available); any Cd74 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• dendritic cells loaded with alphaGal-Cer are defective in activating wild-type Valpha14 invariant NKT cells





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory