immune system
• Valpha14 invariant NKT cell displaya bias in their Vbeta repertoire, with an overrepresentation of Vbeta7
• thymic Valpha14 invariant NKT cells significantly remain in the earlier stages of development compared to controls
• these cells have increased expression of immature markers such as Slamf1 and CD69
• thymic Valpha14 invariant NKT cells at all stages of development in the thymus display increased rates of apoptosis compared to controls
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• Valpha14 invariant NKT cell numbers are reduced 60% in the thymus and 80% in the liver and spleen
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• Valpha14 invariant NKT cells have reduced expression of IL-2 and IL-4 when activated
• IFN-gamma secretion upon activation is similar to controls
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• dendritic cells loaded with alphaGal-Cer are defective in activating wild-type Valpha14 invariant NKT cells
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• Valpha14 invariant NKT cells have reduced expression of IL-2 and IL-4 when activated
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• Valpha14 invariant NKT cells have reduced expression of IL-2 and IL-4 when activated
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hematopoietic system
• Valpha14 invariant NKT cell displaya bias in their Vbeta repertoire, with an overrepresentation of Vbeta7
• thymic Valpha14 invariant NKT cells significantly remain in the earlier stages of development compared to controls
• these cells have increased expression of immature markers such as Slamf1 and CD69
• thymic Valpha14 invariant NKT cells at all stages of development in the thymus display increased rates of apoptosis compared to controls
|
• Valpha14 invariant NKT cell numbers are reduced 60% in the thymus and 80% in the liver and spleen
|
• Valpha14 invariant NKT cells have reduced expression of IL-2 and IL-4 when activated
• IFN-gamma secretion upon activation is similar to controls
|