Analysis Tools
growth/size/body
|
• when dams are treated with doxycycline (dox) until E16, double transgenic offspring are runted postnatally and display a failure to thrive
|
nervous system
|
• modest numbers of T lymphocytes are observed scattered throughout the cerebellum of double transgenic animals that received dox treatment until E16; this is not observed in controls
|
|
• at P14, external granule layer (EGL) persists in mutants that receive dox until E16 whereas in controls the EGL is no longer present
|
|
• at P14, numerous proliferating cells are detected, as well as increased vasculature, when animals received dox until E16
|
|
• double transgenic pups which received dox during development until E16 show significant enlargement of the cerebellum at P14
• gliosis and astrocyte hypertrophy is also observed
|
behavior/neurological
immune system
|
• at P14, IFN-g protein was detectable only in lysates of cerebellum from double transgenic mice that had been released from doxycycline at E16, but not in control samples
|
|
• modest numbers of T lymphocytes are observed scattered throughout the cerebellum of double transgenic animals that received dox treatment until E16; this is not observed in controls
|
