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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il23rtm1.1Kuch
targeted mutation 1.1, Vijay K Kuchroo
MGI:4355925
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il23rtm1.1Kuch/Il23rtm1.1Kuch involves: C57BL/6 MGI:4355926


Genotype
MGI:4355926
hm1
Allelic
Composition		 Il23rtm1.1Kuch/Il23rtm1.1Kuch
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il23rtm1.1Kuch mutation (0 available); any Il23r mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive, alpha-beta T cell physiology ( J:151907 )
• Th17 T cells secrete less IL-9 during secondary stimulation
decreased interleukin-9 secretion ( J:151907 )
• IL-9 secretion by Th17 T cells is reduced during secondary stimulation

hematopoietic system
abnormal CD4-positive, alpha-beta T cell physiology ( J:151907 )
• Th17 T cells secrete less IL-9 during secondary stimulation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory