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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccl2tm1.1Tyos
targeted mutation 1.1, Teizo Yoshimura
MGI:4355946
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccl2tm1.1Tyos/Ccl2tm1.1Tyos involves: 129S1/Sv MGI:5515894
hm2
 		Ccl2tm1.1Tyos/Ccl2tm1.1Tyos involves: 129S1/Sv * C57BL/6 MGI:4355947


Genotype
MGI:5515894
hm1
Allelic
Composition		 Ccl2tm1.1Tyos/Ccl2tm1.1Tyos
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl2tm1.1Tyos mutation (2 available); any Ccl2 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased dendritic cell number ( J:199611 )
• reduced recruitment of monocyte-derived dendritic calls into inflamed lungs
abnormal dendritic cell physiology ( J:199611 )
• reduced recruitment of monocyte-derived dendritic calls into inflamed lungs
abnormal dendritic cell chemotaxis ( J:199611 )
• impaired in response to bronchioalveolar lavage fluid from inflamed lungs

cellular
abnormal dendritic cell chemotaxis ( J:199611 )
• impaired in response to bronchioalveolar lavage fluid from inflamed lungs

hematopoietic system
abnormal dendritic cell chemotaxis ( J:199611 )
• impaired in response to bronchioalveolar lavage fluid from inflamed lungs
decreased dendritic cell number ( J:199611 )
• reduced recruitment of monocyte-derived dendritic calls into inflamed lungs




Genotype
MGI:4355947
hm2
Allelic
Composition		 Ccl2tm1.1Tyos/Ccl2tm1.1Tyos
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl2tm1.1Tyos mutation (2 available); any Ccl2 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired macrophage chemotaxis ( J:151874 )
• only half the number of macrophages are recruited to the peritoneum in an induced peritonitis model as occurs in wild-type controls
abnormal neutrophil physiology ( J:151874 )
• the number of neutrophils recruited to the peritoneum in an induced peritonitis model is almost double that controls
abnormal chemokine level ( J:151874 )
• in thioglycollate- or zymosan- induced peritonitis models, no Ccl2 chemokine is detected but 4-fold higher levels of Ccl7 are present in peritoneal fluid
abnormal chemokine secretion ( J:151874 )
• as expected, there is no Ccl2 (MCP-1) secretion by peritoneal macrophages activated in vitro
• unexpectedly, there is a 6-fold increase in Ccl7 (MCP-3) secretion and a 4-fold increase in Ccl12 (MCP-5) by these same activated macrophages

homeostasis/metabolism
abnormal chemokine level ( J:151874 )
• in thioglycollate- or zymosan- induced peritonitis models, no Ccl2 chemokine is detected but 4-fold higher levels of Ccl7 are present in peritoneal fluid

cellular
impaired macrophage chemotaxis ( J:151874 )
• only half the number of macrophages are recruited to the peritoneum in an induced peritonitis model as occurs in wild-type controls

hematopoietic system
impaired macrophage chemotaxis ( J:151874 )
• only half the number of macrophages are recruited to the peritoneum in an induced peritonitis model as occurs in wild-type controls
abnormal neutrophil physiology ( J:151874 )
• the number of neutrophils recruited to the peritoneum in an induced peritonitis model is almost double that controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory