Phenotypes associated with this allele

• Allele Symbol: Sstr4^tm1Szo
• Allele Name: targeted mutation 1, Janos Szolcsanyi
• Allele ID: MGI:4355975
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sstr4^tm1Szo/Sstr4^tm1Szo	B6.129P2-Sstr4^tm1Szo	MGI:4355995

Genotype
MGI:4355995

hm1

• Allelic Composition: Sstr4^tm1Szo/Sstr4^tm1Szo
• Genetic Background: B6.129P2-Sstr4^tm1Szo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hyperalgesia ( J:152015 )

• carrageenan administration leads to a greater drop in nociceptive threshold than in controls

immune system

abnormal granulocyte morphology ( J:152015 )

• greatly increased MPO activity suggests 3-fold greater number of granulocytes in the lung after LPS administration

abnormal neutrophil physiology ( J:152015 )

• neutrophil recruitment to the lungs after LPS administration is greatly enhanced compared to controls

increased susceptibility to type IV hypersensitivity reaction ( J:152015 )

• oxazolone-induced allergic contact dermatitis in the ear leads to swelling that is twice the thickness of controls

increased interferon-gamma secretion ( J:152015 )

• IFN-gamma secretion in the lung after LPS administration is greater in these mice than in controls

increased interleukin-1 beta secretion ( J:152015 )

• IL-1beta secretion in the lung after LPS administration is greater in these mice than in controls

• IL-1beta secretion is also increased in oxazolone-induced allergic contact dermatitis

increased tumor necrosis factor secretion ( J:152015 )

• TNF secretion in the lung after LPS administration is greater in these mice than in controls

• TNF secretion is also increased in oxazolone-induced allergic contact dermatitis

homeostasis/metabolism

edema ( J:152015 )

• edema caused by carrageenan administration are significantly greater than in controls

pulmonary edema ( J:152015 )

• pulmonary edema induced by LPS is more severe in these mice than controls with the destruction of the alveolar spaces by the large number of infiltrating leukocytes and the hyperplasia of goblet cells much more pronounced

• mice have a 50% higher inflammatory score after LPS administration than controls

respiratory system

pulmonary edema ( J:152015 )

• pulmonary edema induced by LPS is more severe in these mice than controls with the destruction of the alveolar spaces by the large number of infiltrating leukocytes and the hyperplasia of goblet cells much more pronounced

• mice have a 50% higher inflammatory score after LPS administration than controls

increased airway responsiveness ( J:152015 )

• carbachol-evoked bronchoconstriction in mice administered LPS is greater in mutant mice than in controls

hematopoietic system

abnormal granulocyte morphology ( J:152015 )

• greatly increased MPO activity suggests 3-fold greater number of granulocytes in the lung after LPS administration

abnormal neutrophil physiology ( J:152015 )

• neutrophil recruitment to the lungs after LPS administration is greatly enhanced compared to controls