All Phenotypes Kif7<maki> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kif7^maki
matariki
MGI:4355980

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kif7^maki/Kif7^maki	involves: C57BL/6J	MGI:5495414
cx2	Gli3^Xt/? Kif7^maki/Kif7^maki Tg(Hlxb9-GFP)1Tmj/?	involves: 101/H * C3H/HeH * C57BL/6J * CBA/H * FVB/N	MGI:4355989
cx3	Gli2^tm1Alj/Gli2^tm1Alj Kif7^maki/Kif7^maki Tg(Hlxb9-GFP)1Tmj/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	MGI:4355988
cx4	Kif7^maki/Kif7^maki Ptch1^tm1Mps/Ptch1^tm1Mps Tg(Hlxb9-GFP)1Tmj/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	MGI:4355990
cx5	Kif7^maki/Kif7^maki Tg(Hlxb9-GFP)1Tmj/?	involves: C57BL/6J * FVB/N	MGI:4355986
cx6	Kif7^maki/Kif7^maki Smo^bnb/Smo^bnb Tg(Hlxb9-GFP)1Tmj/?	involves: C57BL/6J * FVB/N	MGI:4355987
cx7	Ift172^wim/Ift172^wim Kif7^maki/Kif7^maki Tg(Hlxb9-GFP)1Tmj/?	involves: C57BL/6J * FVB/N	MGI:4355991
cx8	Dync2h1^mmi/Dync2h1^mmi Kif7^maki/Kif7^maki Tg(Hlxb9-GFP)1Tmj/?	involves: C57BL/6J * FVB/N	MGI:4355992

Allelic Composition	Kif7^maki/Kif7^maki
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif7^maki mutation (0 available); any Kif7 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Diaphragmatic hernia in Kif7^maki/Kif7^maki mice

muscle

abnormal diaphragm central tendon morphology ( J:197449 )

• central tendon patterning defects at E17.5

diaphragmatic hernia ( J:197449 )

• left-sided communicating diaphragmatic hernias

skeleton

abnormal diaphragm central tendon morphology ( J:197449 )

• central tendon patterning defects at E17.5

Allelic Composition	Gli3^Xt/? Kif7^maki/Kif7^maki Tg(Hlxb9-GFP)1Tmj/?
Genetic Background	involves: 101/H * C3H/HeH * C57BL/6J * CBA/H * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt mutation (1 available); any Gli3 mutation (81 available)
Kif7^maki mutation (0 available); any Kif7 mutation (40 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neural tube morphology ( J:151965 )

• expansion of the ventral neural cell types is increased compared to Kif7 single mutants

embryo

abnormal neural tube morphology ( J:151965 )

• expansion of the ventral neural cell types is increased compared to Kif7 single mutants

Allelic Composition	Gli2^tm1Alj/Gli2^tm1Alj Kif7^maki/Kif7^maki Tg(Hlxb9-GFP)1Tmj/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm1Alj mutation (0 available); any Gli2 mutation (169 available)
Kif7^maki mutation (0 available); any Kif7 mutation (40 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neural tube morphology ( J:151965 )

• unlike in Kif7 single mutants, in compound mutants the motor neuron domain is not expanded dorsally and the Nkx2.2+ domain is absent

absent floor plate ( J:151965 )

embryo

abnormal neural tube morphology ( J:151965 )

• unlike in Kif7 single mutants, in compound mutants the motor neuron domain is not expanded dorsally and the Nkx2.2+ domain is absent

absent floor plate ( J:151965 )

Allelic Composition	Kif7^maki/Kif7^maki Ptch1^tm1Mps/Ptch1^tm1Mps Tg(Hlxb9-GFP)1Tmj/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif7^maki mutation (0 available); any Kif7 mutation (40 available)
Ptch1^tm1Mps mutation (2 available); any Ptch1 mutation (115 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:151965 )

• compound mutants develop until E10.5, unlike Ptch1 single mutants that arrest at about E9.0

nervous system

abnormal neural tube morphology ( J:151965 )

• ventral cell types are expanded to encompass about 3/4 of the neural plate

• this expansion is less than that seen in Ptch1 single mutants

embryo

abnormal neural tube morphology ( J:151965 )

• ventral cell types are expanded to encompass about 3/4 of the neural plate

• this expansion is less than that seen in Ptch1 single mutants

Allelic Composition	Kif7^maki/Kif7^maki Tg(Hlxb9-GFP)1Tmj/?
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif7^maki mutation (0 available); any Kif7 mutation (40 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:151965 )

• die at the end of gestation

nervous system

abnormal neural tube morphology ( J:151965 )

• at E10.5 the motor neuron region is expanded dorsally

abnormal motor neuron morphology ( J:151965 )

• at E10.5 the motor neuron region is expanded dorsally in the neural tube

increased motor neuron number ( J:151965 )

• at E10.5 in the neural tube

limbs/digits/tail

preaxial polydactyly ( J:151965 )

• preaxial polydactyly

embryo

abnormal neural tube morphology ( J:151965 )

• at E10.5 the motor neuron region is expanded dorsally

Allelic Composition	Kif7^maki/Kif7^maki Smo^bnb/Smo^bnb Tg(Hlxb9-GFP)1Tmj/?
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif7^maki mutation (0 available); any Kif7 mutation (40 available)
Smo^bnb mutation (0 available); any Smo mutation (39 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:151965 )

• compound mutants develop until E10.5, unlike Smo single mutants that die at or before E9.0

nervous system

nervous system phenotype ( J:151965 )

N	• unlike Smo single mutants, compound mutants develop ventral neural types

Allelic Composition	Ift172^wim/Ift172^wim Kif7^maki/Kif7^maki Tg(Hlxb9-GFP)1Tmj/?
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift172^wim mutation (0 available); any Ift172 mutation (75 available)
Kif7^maki mutation (0 available); any Kif7 mutation (40 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neural tube morphology ( J:151965 )

• phenotype is indistinguishable for that of Ift172 single mutants with the absence of Nkx2.2+ cells and few motor neurons in the neural tube

absent floor plate ( J:151965 )

embryo

abnormal neural tube morphology ( J:151965 )

• phenotype is indistinguishable for that of Ift172 single mutants with the absence of Nkx2.2+ cells and few motor neurons in the neural tube

absent floor plate ( J:151965 )

Allelic Composition	Dync2h1^mmi/Dync2h1^mmi Kif7^maki/Kif7^maki Tg(Hlxb9-GFP)1Tmj/?
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dync2h1^mmi mutation (0 available); any Dync2h1 mutation (215 available)
Kif7^maki mutation (0 available); any Kif7 mutation (40 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neural tube morphology ( J:151965 )

• lack ventral neural cell types

abnormal motor neuron morphology ( J:151965 )

• have only a very small number of motor neurons at all rostrocaudal positions in the spinal cord

• loss of motor neurons is increased compared to Dync2h1 single mutants

embryo

abnormal neural tube morphology ( J:151965 )

• lack ventral neural cell types

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