Phenotypes associated with this allele

• Allele Symbol: Cr2^{tm2.1(HLA-A)Crr}
• Allele Name: targeted mutation 2.1, Michael C Carroll
• Allele ID: MGI:4356009
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cr2^tm2.1(HLA-A)Crr/Cr2^tm2.1(HLA-A)Crr	involves: C57BL/6	MGI:4356057
cx2	Cr2^tm2.1(HLA-A)Crr/Cr2^tm2.1(HLA-A)Crr Tg(IghelMD4)4Ccg/?	involves: C57BL/6	MGI:4356056

Genotype
MGI:4356057

hm1

• Allelic Composition: Cr2^{tm2.1(HLA-A)Crr}/Cr2^{tm2.1(HLA-A)Crr}
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal memory B cell differentiation ( J:151991 )

• bone marrow chimeric mice have reduced ability to generate memory B cells in response to low-dose antigen

abnormal B cell physiology ( J:151991 )

• B cells fail to internalize complement coated immune complexes

• bone marrow chimeric mice containing mutant B cells have a decreased ability to produce antigen-specific antibodies to low doses of antigen

abnormal class switch recombination ( J:151991 )

• bone marrow chimeric mice have enhanced ability in class switch recombination in response to low dose antigen

hematopoietic system

abnormal memory B cell differentiation ( J:151991 )

• bone marrow chimeric mice have reduced ability to generate memory B cells in response to low-dose antigen

abnormal B cell physiology ( J:151991 )

• B cells fail to internalize complement coated immune complexes

• bone marrow chimeric mice containing mutant B cells have a decreased ability to produce antigen-specific antibodies to low doses of antigen

abnormal class switch recombination ( J:151991 )

• bone marrow chimeric mice have enhanced ability in class switch recombination in response to low dose antigen

Genotype
MGI:4356056

cx2

• Allelic Composition: Cr2^{tm2.1(HLA-A)Crr}/Cr2^{tm2.1(HLA-A)Crr}; Tg(IghelMD4)4Ccg/?
• Genetic Background: involves: C57BL/6

immune system

abnormal B cell activation ( J:151991 )

• B cells fail to react to sub-optimal doses of antigen coated in C3 complement

• B cells are also unresponsive to a suboptimal level of anti-IgM, anti-CD40, and C3d

hematopoietic system

abnormal B cell activation ( J:151991 )

• B cells fail to react to sub-optimal doses of antigen coated in C3 complement

• B cells are also unresponsive to a suboptimal level of anti-IgM, anti-CD40, and C3d