Phenotypes associated with this allele

• Allele Symbol: Tg(Nefh-cre)7Kul
• Allele Name: transgene insertion 7, Ashok B Kulkarni
• Allele ID: MGI:4356089
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kifap3^tm1Noh/Kifap3^tm1.1Noh Tg(Nefh-cre)7Kul/0	involves: 129S4/SvJae * C57BL/6J	MGI:3581282

Genotype
MGI:3581282

cn1

• Allelic Composition: Kifap3^tm1Noh/Kifap3^tm1.1Noh; Tg(Nefh-cre)7Kul/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:98470 )

• did not survive for more than one day after birth

nervous system

abnormal brain morphology ( J:98470 )

• tumor-like focal progressive hypertrophy of neural progenitor cells, with cells dividing faster and fewer proportion of cells exciting the cell cycle

abnormal embryonic neuroepithelial layer differentiation ( J:98470 )

• formation of neuroepithelial tumor-like rosettes that were similar to the rosettes in human primitive neuroectodermal tumors or in ependymoblastoma

increased brain size ( J:98470 )

abnormal forebrain morphology ( J:98470 )

• severe dysplasia of the midline structure of the forebrain

abnormal cerebral cortex morphology ( J:98470 )

• hypertrophic nodules of neural progenitor cells popped out from the limiting membrane of the ventricular zone and formed multilayered rosettes in the mantle zone

• lumina were occasionally filled with choroid-plexus-like eosinophilic cells and undifferentiated neural progenitor cells, surrounded by ependymal lining with many mitotic figures

abnormal spinal cord morphology ( J:98470 )

• accelerated cell proliferation in the spinal cord

embryo

abnormal embryonic neuroepithelial layer differentiation ( J:98470 )

• formation of neuroepithelial tumor-like rosettes that were similar to the rosettes in human primitive neuroectodermal tumors or in ependymoblastoma