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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pcdhatm5.1Tyag
targeted mutation 5.1, Takeshi Yagi
MGI:4356090
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pcdhatm5.1Tyag/Pcdhatm5.1Tyag B6.Cg-Pcdhatm5.1Tyag MGI:4356105


Genotype
MGI:4356105
hm1
Allelic
Composition
Pcdhatm5.1Tyag/Pcdhatm5.1Tyag
Genetic
Background
B6.Cg-Pcdhatm5.1Tyag
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdhatm5.1Tyag mutation (2 available); any Pcdha mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• serotonergic fibers are increased in the lacunosum-moleculare (170%) and decreased in the dentate gyrus (41%) compared to in wild-type mice
• serotonergic fibers are decreased 41% in the dentate gyrus compared to in wild-type mice
• mice exhibit abnormal serotonergic fibers in the cerebral cortex, hippocampus, basal ganglia, and thalamus compared to in wild-type mice

growth/size/body
• between 12 and 96 weeks

behavior/neurological
• resulting in lesions

homeostasis/metabolism
• at 10 weeks, the level of serotonin is higher in the hippocampus compared to in wild-type mice

integument
• by 36 weeks, mice develop lesions on their head, neck, and snout unlike in wild-type mice
• at 96 weeks, 50% of mice exhibit lesions on their bodies unlike wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory