immune system
• there are almost 10-fold lower thymocytes compared to controls
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• the percentage of single-positive thymocytes is increased
• the percentage of double-positive thymocytes is decreased compared to controls
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• some CD8-single positive NKT cells are found in the liver
• iNKT T cells have a bias towards expressing a receptor encoded in part by the TCRVbeta8 gene segment
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• splenocyte numbers are almost cut in half
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• IgG1 levels are increased about 5-fold
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• IgG2a levels are decreased about 10-fold
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• GM-CSF levels are more than 10-fold higher than controls 4 hours after alphaGalCer injection
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• IFN-gamma levels are more than 10-fold higher than controls 4 hours after alphaGalCer injection
• increased IFN-gamma levels result from increased numbers of iNKT cells
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• IL-10 levels are more than 10-fold higher than controls 4 hours after alphaGalCer injection
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• IL-2 levels are more than 10-fold higher than controls 4 hours after alphaGalCer injection
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• IL-4 levels are more than 10-fold higher than controls 4 hours after alphaGalCer injection
• increased IL-4 levels result from increased numbers of iNKT cells
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liver/biliary system
• the number of lymphocytes in the liver is more than double of controls
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hematopoietic system
• there are almost 10-fold lower thymocytes compared to controls
|
• the percentage of single-positive thymocytes is increased
• the percentage of double-positive thymocytes is decreased compared to controls
|
• some CD8-single positive NKT cells are found in the liver
• iNKT T cells have a bias towards expressing a receptor encoded in part by the TCRVbeta8 gene segment
|
• splenocyte numbers are almost cut in half
|
• IgG1 levels are increased about 5-fold
|
• IgG2a levels are decreased about 10-fold
|
endocrine/exocrine glands
• there are almost 10-fold lower thymocytes compared to controls
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