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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		TcraLn1Ogu
recombination line 1, Atsuo Ogura
MGI:4356137
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		TcraLn1Ogu/Tcra+ involves: 129/Sv * C57BL/6 MGI:4356164
cx2
 		TcraLn1Ogu/Tcra+
TcrbLn1Ogu/Tcrb+ 		involves: 129/Sv * C57BL/6 MGI:4356144
cx3
 		Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw
TcraLn1Ogu/Tcra+ 		involves: 129/Sv * C57BL/6 MGI:4356165


Genotype
MGI:4356164
ht1
Allelic
Composition		 TcraLn1Ogu/Tcra+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
TcraLn1Ogu mutation (0 available); any Tcra mutation (101 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:152041 )
• there are almost 10-fold lower thymocytes compared to controls
abnormal T cell subpopulation ratio ( J:152041 )
• the percentage of single-positive thymocytes is increased
• the percentage of double-positive thymocytes is decreased compared to controls
abnormal NK T cell morphology ( J:152041 )
• some CD8-single positive NKT cells are found in the liver
• iNKT T cells have a bias towards expressing a receptor encoded in part by the TCRVbeta8 gene segment
decreased splenocyte number ( J:152041 )
• splenocyte numbers are almost cut in half
increased IgG1 level ( J:152041 )
• IgG1 levels are increased about 5-fold
decreased IgG2a level ( J:152041 )
• IgG2a levels are decreased about 10-fold
abnormal cytokine secretion ( J:152041 )
• GM-CSF levels are more than 10-fold higher than controls 4 hours after alphaGalCer injection
increased interferon-gamma secretion ( J:152041 )
• IFN-gamma levels are more than 10-fold higher than controls 4 hours after alphaGalCer injection
• increased IFN-gamma levels result from increased numbers of iNKT cells
increased interleukin-10 secretion ( J:152041 )
• IL-10 levels are more than 10-fold higher than controls 4 hours after alphaGalCer injection
increased interleukin-2 secretion ( J:152041 )
• IL-2 levels are more than 10-fold higher than controls 4 hours after alphaGalCer injection
increased interleukin-4 secretion ( J:152041 )
• IL-4 levels are more than 10-fold higher than controls 4 hours after alphaGalCer injection
• increased IL-4 levels result from increased numbers of iNKT cells

liver/biliary system
abnormal liver morphology ( J:152041 )
• the number of lymphocytes in the liver is more than double of controls

hematopoietic system
decreased thymocyte number ( J:152041 )
• there are almost 10-fold lower thymocytes compared to controls
abnormal T cell subpopulation ratio ( J:152041 )
• the percentage of single-positive thymocytes is increased
• the percentage of double-positive thymocytes is decreased compared to controls
abnormal NK T cell morphology ( J:152041 )
• some CD8-single positive NKT cells are found in the liver
• iNKT T cells have a bias towards expressing a receptor encoded in part by the TCRVbeta8 gene segment
decreased splenocyte number ( J:152041 )
• splenocyte numbers are almost cut in half
increased IgG1 level ( J:152041 )
• IgG1 levels are increased about 5-fold
decreased IgG2a level ( J:152041 )
• IgG2a levels are decreased about 10-fold

endocrine/exocrine glands
decreased thymocyte number ( J:152041 )
• there are almost 10-fold lower thymocytes compared to controls




Genotype
MGI:4356144
cx2
Allelic
Composition		 TcraLn1Ogu/Tcra+
TcrbLn1Ogu/Tcrb+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
TcraLn1Ogu mutation (0 available); any Tcra mutation (101 available)
TcrbLn1Ogu mutation (0 available); any Tcrb mutation (97 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:152069 )
• mice are heavier than controls

immune system
abnormal T cell morphology ( J:152069 )
• all T cell express the Vbeta8 gene segment compared to just 20% in controls

hematopoietic system
abnormal T cell morphology ( J:152069 )
• all T cell express the Vbeta8 gene segment compared to just 20% in controls




Genotype
MGI:4356165
cx3
Allelic
Composition		 Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw
TcraLn1Ogu/Tcra+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(3Cd1d2-Cd1d1)1Crw mutation (0 available); any Del(3Cd1d2-Cd1d1)1Crw mutation (0 available)
TcraLn1Ogu mutation (0 available); any Tcra mutation (101 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK T cell morphology ( J:152041 )
• less invariant NKT cells mature in the thymus as determined by binding to CD1d tetramers
• immature iNKT cells that are CD24+CD44dullNK1.1- are very abundant in the thymus

hematopoietic system
abnormal NK T cell morphology ( J:152041 )
• less invariant NKT cells mature in the thymus as determined by binding to CD1d tetramers
• immature iNKT cells that are CD24+CD44dullNK1.1- are very abundant in the thymus




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory