About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccdc86tm1Hfuj
targeted mutation 1, Hodaka Fujii
MGI:4356276
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccdc86tm1Hfuj/Ccdc86tm1Hfuj involves: C57BL/6NTac MGI:4356293
ht2
 		Ccdc86tm1Hfuj/Ccdc86+ involves: C57BL/6NTac MGI:4356294


Genotype
MGI:4356293
hm1
Allelic
Composition		 Ccdc86tm1Hfuj/Ccdc86tm1Hfuj
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc86tm1Hfuj mutation (1 available); any Ccdc86 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:151722 )
• homozygous pups die before birth




Genotype
MGI:4356294
ht2
Allelic
Composition		 Ccdc86tm1Hfuj/Ccdc86+
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc86tm1Hfuj mutation (1 available); any Ccdc86 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell apoptosis ( J:151722 )
• CD4+ T cells are resistant to activation induced cell death
• CD4+ T cells are also resistant to Fas-mediated cell death
abnormal T cell morphology ( J:151722 )
• activated CD4+ T cells have decreased expression of the Fas receptor

immune system
decreased T cell apoptosis ( J:151722 )
• CD4+ T cells are resistant to activation induced cell death
• CD4+ T cells are also resistant to Fas-mediated cell death
abnormal T cell morphology ( J:151722 )
• activated CD4+ T cells have decreased expression of the Fas receptor

cellular
decreased T cell apoptosis ( J:151722 )
• CD4+ T cells are resistant to activation induced cell death
• CD4+ T cells are also resistant to Fas-mediated cell death




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory