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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccdc86tm1Hfuj
targeted mutation 1, Hodaka Fujii
MGI:4356276
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccdc86tm1Hfuj/Ccdc86tm1Hfuj involves: C57BL/6NTac MGI:4356293
ht2
 		Ccdc86tm1Hfuj/Ccdc86+ involves: C57BL/6NTac MGI:4356294


Genotype
MGI:4356293
hm1
Allelic
Composition		 Ccdc86tm1Hfuj/Ccdc86tm1Hfuj
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc86tm1Hfuj mutation (1 available); any Ccdc86 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:151722 )
• homozygous pups die before birth




Genotype
MGI:4356294
ht2
Allelic
Composition		 Ccdc86tm1Hfuj/Ccdc86+
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc86tm1Hfuj mutation (1 available); any Ccdc86 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell apoptosis ( J:151722 )
• CD4+ T cells are resistant to activation induced cell death
• CD4+ T cells are also resistant to Fas-mediated cell death
abnormal T cell morphology ( J:151722 )
• activated CD4+ T cells have decreased expression of the Fas receptor

immune system
decreased T cell apoptosis ( J:151722 )
• CD4+ T cells are resistant to activation induced cell death
• CD4+ T cells are also resistant to Fas-mediated cell death
abnormal T cell morphology ( J:151722 )
• activated CD4+ T cells have decreased expression of the Fas receptor

cellular
decreased T cell apoptosis ( J:151722 )
• CD4+ T cells are resistant to activation induced cell death
• CD4+ T cells are also resistant to Fas-mediated cell death




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory