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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CD2-Ccdc86)1Hfuj
transgene insertion 1, Hodaka Fujii
MGI:4356279
Summary 4 genotypes


Genotype
MGI:4356291
cx1
Allelic
Composition		 Faslpr/Faslpr
Il2ratm1Dw/Il2ratm1Dw
Tg(CD2-Ccdc86)1Hfuj/?
Genetic
Background		 B6.Cg-Il2ratm1Dw Faslpr Tg(CD2-Ccdc86)1Hfuj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (39 available); any Fas mutation (82 available)
Il2ratm1Dw mutation (3 available); any Il2ra mutation (51 available)
Tg(CD2-Ccdc86)1Hfuj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:151722 )
• absence of the Fas receptor prevents the transgene from rescuing the splenomegaly associated with Il2ratm1Dw homozygotes

hematopoietic system
enlarged spleen ( J:151722 )
• absence of the Fas receptor prevents the transgene from rescuing the splenomegaly associated with Il2ratm1Dw homozygotes

growth/size/body
enlarged spleen ( J:151722 )
• absence of the Fas receptor prevents the transgene from rescuing the splenomegaly associated with Il2ratm1Dw homozygotes




Genotype
MGI:4356290
cx2
Allelic
Composition		 Il2ratm1Dw/Il2ratm1Dw
Tg(CD2-Ccdc86)1Hfuj/?
Genetic
Background		 B6.Cg-Il2ratm1Dw Tg(CD2-Ccdc86)1Hfuj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2ratm1Dw mutation (3 available); any Il2ra mutation (51 available)
Tg(CD2-Ccdc86)1Hfuj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:151722 )
N
• the presence of the transgene prevents the splenomegaly, the large number of T cells, and high circulating levels of IL-17 normally found in Il2ratm1Dw homozygotes
increased activated T cell number ( J:151722 )
• high expression of CD44 and CD69 suggests the transgene does not prevent the aberrant activation of peripheral T cells

hematopoietic system
increased activated T cell number ( J:151722 )
• high expression of CD44 and CD69 suggests the transgene does not prevent the aberrant activation of peripheral T cells




Genotype
MGI:4356292
cx3
Allelic
Composition		 Il2rgtm1Wjl/Il2rgtm1Wjl
Tg(CD2-Ccdc86)1Hfuj/?
Genetic
Background		 B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
Tg(CD2-Ccdc86)1Hfuj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:151722 )
N
• the presence of the transgene prevents the splenomegaly associated with Il2rgtm1Wjl homozygotes due to decreased lymphocyte numbers and size
decreased CD4-positive, alpha-beta T cell number ( J:151722 )
• CD4 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
decreased CD8-positive, alpha-beta T cell number ( J:151722 )
• CD8 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
decreased regulatory T cell number ( J:151722 )
• the transgene fails to rescue the decreased numbers of FoxP3+ regulatory T cells associated with Il2rgtm1Wjl homozygotes
decreased splenocyte number ( J:151722 )
• splenocyte number is decreased compared to wild-type and to Il2rgtm1Wjl homozygotes

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:151722 )
• CD4 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
decreased CD8-positive, alpha-beta T cell number ( J:151722 )
• CD8 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
decreased regulatory T cell number ( J:151722 )
• the transgene fails to rescue the decreased numbers of FoxP3+ regulatory T cells associated with Il2rgtm1Wjl homozygotes
decreased splenocyte number ( J:151722 )
• splenocyte number is decreased compared to wild-type and to Il2rgtm1Wjl homozygotes




Genotype
MGI:4356289
tg4
Allelic
Composition		 Tg(CD2-Ccdc86)1Hfuj/?
Genetic
Background		 B6.FVB-Tg(CD2-Ccdc86)1Hfuj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CD2-Ccdc86)1Hfuj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell apoptosis ( J:151722 )
• CD4+ and CD8+ T cells have increased rates of activation induced cell death upon secondary stimulation
abnormal T cell morphology ( J:151722 )
• T cells have increased expression of the Fas receptor

hematopoietic system
increased T cell apoptosis ( J:151722 )
• CD4+ and CD8+ T cells have increased rates of activation induced cell death upon secondary stimulation
abnormal T cell morphology ( J:151722 )
• T cells have increased expression of the Fas receptor

cellular
increased T cell apoptosis ( J:151722 )
• CD4+ and CD8+ T cells have increased rates of activation induced cell death upon secondary stimulation




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory