About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CD2-Ccdc86)1Hfuj
transgene insertion 1, Hodaka Fujii
MGI:4356279
Summary 4 genotypes


Genotype
MGI:4356291
cx1
Allelic
Composition		 Faslpr/Faslpr
Il2ratm1Dw/Il2ratm1Dw
Tg(CD2-Ccdc86)1Hfuj/?
Genetic
Background		 B6.Cg-Il2ratm1Dw Faslpr Tg(CD2-Ccdc86)1Hfuj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (39 available); any Fas mutation (82 available)
Il2ratm1Dw mutation (3 available); any Il2ra mutation (51 available)
Tg(CD2-Ccdc86)1Hfuj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:151722 )
• absence of the Fas receptor prevents the transgene from rescuing the splenomegaly associated with Il2ratm1Dw homozygotes

hematopoietic system
enlarged spleen ( J:151722 )
• absence of the Fas receptor prevents the transgene from rescuing the splenomegaly associated with Il2ratm1Dw homozygotes

growth/size/body
enlarged spleen ( J:151722 )
• absence of the Fas receptor prevents the transgene from rescuing the splenomegaly associated with Il2ratm1Dw homozygotes




Genotype
MGI:4356290
cx2
Allelic
Composition		 Il2ratm1Dw/Il2ratm1Dw
Tg(CD2-Ccdc86)1Hfuj/?
Genetic
Background		 B6.Cg-Il2ratm1Dw Tg(CD2-Ccdc86)1Hfuj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2ratm1Dw mutation (3 available); any Il2ra mutation (51 available)
Tg(CD2-Ccdc86)1Hfuj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:151722 )
N
• the presence of the transgene prevents the splenomegaly, the large number of T cells, and high circulating levels of IL-17 normally found in Il2ratm1Dw homozygotes
increased activated T cell number ( J:151722 )
• high expression of CD44 and CD69 suggests the transgene does not prevent the aberrant activation of peripheral T cells

hematopoietic system
increased activated T cell number ( J:151722 )
• high expression of CD44 and CD69 suggests the transgene does not prevent the aberrant activation of peripheral T cells




Genotype
MGI:4356292
cx3
Allelic
Composition		 Il2rgtm1Wjl/Il2rgtm1Wjl
Tg(CD2-Ccdc86)1Hfuj/?
Genetic
Background		 B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (178 available)
Tg(CD2-Ccdc86)1Hfuj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:151722 )
N
• the presence of the transgene prevents the splenomegaly associated with Il2rgtm1Wjl homozygotes due to decreased lymphocyte numbers and size
decreased CD4-positive, alpha-beta T cell number ( J:151722 )
• CD4 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
decreased CD8-positive, alpha-beta T cell number ( J:151722 )
• CD8 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
decreased regulatory T cell number ( J:151722 )
• the transgene fails to rescue the decreased numbers of FoxP3+ regulatory T cells associated with Il2rgtm1Wjl homozygotes
decreased splenocyte number ( J:151722 )
• splenocyte number is decreased compared to wild-type and to Il2rgtm1Wjl homozygotes

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:151722 )
• CD4 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
decreased CD8-positive, alpha-beta T cell number ( J:151722 )
• CD8 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
decreased regulatory T cell number ( J:151722 )
• the transgene fails to rescue the decreased numbers of FoxP3+ regulatory T cells associated with Il2rgtm1Wjl homozygotes
decreased splenocyte number ( J:151722 )
• splenocyte number is decreased compared to wild-type and to Il2rgtm1Wjl homozygotes




Genotype
MGI:4356289
tg4
Allelic
Composition		 Tg(CD2-Ccdc86)1Hfuj/?
Genetic
Background		 B6.FVB-Tg(CD2-Ccdc86)1Hfuj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CD2-Ccdc86)1Hfuj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell apoptosis ( J:151722 )
• CD4+ and CD8+ T cells have increased rates of activation induced cell death upon secondary stimulation
abnormal T cell morphology ( J:151722 )
• T cells have increased expression of the Fas receptor

hematopoietic system
increased T cell apoptosis ( J:151722 )
• CD4+ and CD8+ T cells have increased rates of activation induced cell death upon secondary stimulation
abnormal T cell morphology ( J:151722 )
• T cells have increased expression of the Fas receptor

cellular
increased T cell apoptosis ( J:151722 )
• CD4+ and CD8+ T cells have increased rates of activation induced cell death upon secondary stimulation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory