Phenotypes associated with this allele

• Allele Symbol: Lrrk2^tm1.1Shn
• Allele Name: targeted mutation 1.1, Jie Shen
• Allele ID: MGI:4356349
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrrk2^tm1.1Shn/Lrrk2^tm1.1Shn	involves: 129 * C57BL/6	MGI:4356426

Genotype
MGI:4356426

hm1

• Allelic Composition: Lrrk2^tm1.1Shn/Lrrk2^tm1.1Shn
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:151944 )

N • mice exhibit normal dopaminergic neurons and striatal catecholamine levels

abnormal action potential ( J:151944 )

• the response of nigral neurons to dopamine treatment exhibits a smaller amplitude and shorter duration of hyperpolarization than in similarly treated wild-type cells

• dopamine-treated nigral neurons exhibit a shorter time to predrug firing activity compared with similarly treated wild-type neurons

• quinpirole-treated nigral neurons are less sensitive than similarly treated wild-type neurons

• amphetamine-treated neurons exhibit a shorter cessation of firing compared with similarly treated wild-type neurons with smaller hyperpolarization

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:151944 )

• the response of nigral neurons to dopamine treatment exhibits a smaller amplitude and shorter duration of hyperpolarization than in similarly treated wild-type cells

• dopamine-treated nigral neurons exhibit a shorter time to predrug firing activity compared with similarly treated wild-type neurons

decreased physiological sensitivity to xenobiotic ( J:151944 )

• amphetamine-treated neurons exhibit a shorter cessation of firing compared with similarly treated wild-type neurons with smaller hyperpolarization

behavior/neurological

impaired behavioral response to xenobiotic ( J:151944 )

• following treatment with amphetamine, mice fail to exhibit an increase in locomotor activity unlike similarly treated wild-type mice

• mice treated with quinpirole do not exhibit as much of a decrease in locomotor activity (horizontal and vertical movements) as similarly treated wild-type mice

• quinpirole-treated nigral neurons are less sensitive than similarly treated wild-type neurons

impaired behavioral response to addictive substance ( J:151944 )

• following treatment with amphetamine, mice fail to exhibit an increase in locomotor activity unlike similarly treated wild-type mice

endocrine/exocrine glands

abnormal adrenal gland secretion ( J:151944 )

• adrenal chromaffin cells exhibit reduced catecholamine release per cell, quantal size, and frequency of release events when stimulated with high potassium ion compared to similarly treated wild-type cells

cellular

abnormal Golgi vesicle transport ( J:314451 )

• cholera toxin B translocation from the cell surface to the trans-Golgi Network (retrograde translocation) is increased in primary astrocytes

• anterograde transport of GPI proteins from the trans-Golgi Network to the plasma membrane is enhanced in primary astrocytes

• treatment with the LRRK2 kinase inhibitor MLi2 reverses the increased cholera toxin B trafficking