Phenotypes associated with this allele

• Allele Symbol: Fto^I367F
• Allele Name: Ile 367 Phe
• Allele ID: MGI:4356560
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fto^I367F/Fto^I367F	involves: C3H/HeH * C57BL/6J	MGI:4357689
ht2	Fto^I367F/Fto^+	involves: C3H/HeH * C57BL/6J	MGI:4357690

Genotype
MGI:4357689

hm1

• Allelic Composition: Fto^I367F/Fto^I367F
• Genetic Background: involves: C3H/HeH * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:152163 )

• in 24 week old fasting male mice but not at 12 or 16 weeks or male mice fed a high fat diet

increased circulating glucagon level ( J:152163 )

• in 24 week old fasting male mice or male mice fed a high fat diet

decreased circulating insulin level ( J:152163 )

• when male mice are fed a high fat diet

increased circulating leptin level ( J:152163 )

• in 8 but not 24 weeks old fasting male mice

increased circulating cholesterol level ( J:152163 )

• in 24 week old fasting male mice

increased circulating HDL cholesterol level ( J:152163 )

• in 24 week old fasting male mice or male mice fed a high fat diet

increased circulating triglyceride level ( J:152163 )

• in 24 week old fasting male mice or male mice fed a high fat diet

abnormal urine catecholamine level ( J:152163 )

• at 10 weeks, male mice exhibit increased urine norepinephrine and dopamine levels compared to in wild-type mice

• at 20 weeks, male mice exhibit increased urine dopamine levels compared to in wild-type mice

decreased carbon dioxide production ( J:152163 )

• during the dark phase when male mice are fed a high fat diet

increased carbon dioxide production ( J:152163 )

• in 18 week old male mice

increased oxygen consumption ( J:152163 )

• in 18 week old male mice

increased respiratory quotient ( J:152163 )

• 18 week old male mice exhibit increased respiratory exchange rate compared with similarly treated wild-type mice

• when fed a high fat diet, male mice exhibit higher respiratory exchange rate during the dark phase compared with similarly treated wild-type mice

abnormal metabolism ( J:152163 )

• whole body metabolism in male is increased with a switch to relatively more carbohydrate metabolism than in wild-type mice

growth/size/body

increased lean body mass ( J:152163 )

• when male mice are fed a high fat diet

decreased body weight ( J:152163 )

• beginning at 12 weeks, male mice exhibit a maturity-onset reduction in body weight compared with wild-type mice

• at 24 weeks, male mice weigh 10% less than wild-type mice

• however, female mice maintain normal body weight

adipose tissue

decreased total body fat amount ( J:152163 )

• at 24 weeks, male mice exhibit a 16% to 18% decrease in total fat mass compared with wild-type mice

• when fed a high fat diet, male mice exhibit reduced fat mass compared to similarly treated wild-type mice

decreased percent body fat/body weight ( J:152163 )

• in 24 week old male mice

renal/urinary system

abnormal urine catecholamine level ( J:152163 )

• at 10 weeks, male mice exhibit increased urine norepinephrine and dopamine levels compared to in wild-type mice

• at 20 weeks, male mice exhibit increased urine dopamine levels compared to in wild-type mice

Genotype
MGI:4357690

ht2

• Allelic Composition: Fto^I367F/Fto⁺
• Genetic Background: involves: C3H/HeH * C57BL/6J

homeostasis/metabolism

increased carbon dioxide production ( J:152163 )

• in 18 week old male mice

increased oxygen consumption ( J:152163 )

• in 18 week old male mice

increased respiratory quotient ( J:152163 )

• 18 week old male mice exhibit increased respiratory exchange rate compared with similarly treated wild-type mice

abnormal metabolism ( J:152163 )

• whole body metabolism in male is increased with a switch to relatively more carbohydrate metabolism than in wild-type mice

growth/size/body

decreased body weight ( J:152163 )

• beginning at 12 weeks, male mice exhibit a maturity-onset reduction in body weight compared with wild-type mice

• at 24 weeks, male mice weigh 10% less than wild-type mice

• however, female mice maintain normal body weight

adipose tissue

decreased total body fat amount ( J:152163 )

• at 24 weeks, male mice exhibit a 16% to 18% decrease in total fat mass compared with wild-type mice

decreased percent body fat/body weight ( J:152163 )

• in 24 week old male mice