Phenotypes associated with this allele

• Allele Symbol: Map3k14^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:4357692
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map3k14^m1Btlr/Map3k14^m1Btlr	C57BL/6J-Map3k14^m1Btlr	MGI:4357695
hm2	Map3k14^m1Btlr/Map3k14^m1Btlr	involves: C57BL/6J	MGI:5429189

Genotype
MGI:4357695

hm1

• Allelic Composition: Map3k14^m1Btlr/Map3k14^m1Btlr
• Genetic Background: C57BL/6J-Map3k14^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

arrested B cell differentiation ( J:152065 )

• peripheral B cells of homozygous mutant mice express high levels of surface IgM and lack surface expression of CD23 and CD21/CD35, consistent with a block in B cell development from the T1 to the T2 stage

decreased B cell number ( J:152065 )

• mice homozygous for this mutation exhibit reduced numbers of peripheral B lymphocytes

abnormal B cell activation ( J:152065 )

• on day 28 after the first of two intraperitoneal injections, two weeks apart, with 2x10⁶ IU of a Semliki Forest Virus-based recombinant suicide vector encoding the model antigen beta-galactosidase (rSFV-GAL), the index G3 mouse had no detectable GAL-specific serum IgG

decreased IgG level ( J:152065 )

• on day 28 after the first of two intraperitoneal injections, two weeks apart, with 2x10⁶ IU of a Semliki Forest Virus-based recombinant suicide vector encoding the model antigen beta-galactosidase (rSFV-GAL), the index G3 mouse had no detectable GAL-specific serum IgG

immune system

arrested B cell differentiation ( J:152065 )

• peripheral B cells of homozygous mutant mice express high levels of surface IgM and lack surface expression of CD23 and CD21/CD35, consistent with a block in B cell development from the T1 to the T2 stage

decreased B cell number ( J:152065 )

• mice homozygous for this mutation exhibit reduced numbers of peripheral B lymphocytes

abnormal B cell activation ( J:152065 )

• on day 28 after the first of two intraperitoneal injections, two weeks apart, with 2x10⁶ IU of a Semliki Forest Virus-based recombinant suicide vector encoding the model antigen beta-galactosidase (rSFV-GAL), the index G3 mouse had no detectable GAL-specific serum IgG

decreased IgG level ( J:152065 )

• on day 28 after the first of two intraperitoneal injections, two weeks apart, with 2x10⁶ IU of a Semliki Forest Virus-based recombinant suicide vector encoding the model antigen beta-galactosidase (rSFV-GAL), the index G3 mouse had no detectable GAL-specific serum IgG

absent lymph nodes ( J:152065 )

• homozygous mutant mice lack secondary lymphoid organs

Genotype
MGI:5429189

hm2

• Allelic Composition: Map3k14^m1Btlr/Map3k14^m1Btlr
• Genetic Background: involves: C57BL/6J

immune system

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

arrested B cell differentiation ( J:185495 )

• at T1

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

hematopoietic system

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

arrested B cell differentiation ( J:185495 )

• at T1

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen