Phenotypes associated with this allele

• Allele Symbol: Lrrk2^tm1Arte
• Allele Name: targeted mutation 1, TaconicArtemis
• Allele ID: MGI:4357791
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrrk2^tm1Arte/Lrrk2^tm1Arte	involves: C57BL/6N	MGI:4357792

Genotype
MGI:4357792

hm1

• Allelic Composition: Lrrk2^tm1Arte/Lrrk2^tm1Arte
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampal mossy fiber morphology ( J:206546 )

• increased volume of the supra-pyramidal and intra-infra-pyramidal mossy fiber projections

• however, mice exhibit normal volume of Hilar mossy fibers

abnormal dendrite morphology ( J:206546 )

• increased dendritic length, branching and complexity of young immature neurons in the adult dentate gyrus

increased neuronal precursor cell number ( J:206546 )

• DCX+ hippocampal neuroblasts in the adult dentate gyrus

• increased density of early and intermediate DCX+ neuroblasts in the adult dentate gyrus

• however, mice exhibit normal numbers of late neuroblasts