About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc4a1tm1Phsl
targeted mutation 1, Philip S Low
MGI:4357799
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slc4a1tm1Phsl/Slc4a1tm1Phsl involves: 129 * 129S6/SvEvTac * Black Swiss MGI:4357833
ht2
 		Slc4a1tm1Phsl/Slc4a1+ involves: 129 * 129S6/SvEvTac * Black Swiss MGI:4357834


Genotype
MGI:4357833
hm1
Allelic
Composition		 Slc4a1tm1Phsl/Slc4a1tm1Phsl
Genetic
Background		 involves: 129 * 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc4a1tm1Phsl mutation (0 available); any Slc4a1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:152245 )
• only 80% of mice survive until weaning

hematopoietic system
enlarged spleen ( J:152245 )
• mice have massive splenomegaly
abnormal erythrocyte morphology ( J:152245 )
• red blood cell lifespan is 2 days compared to 60 in controls
low mean erythrocyte cell number ( J:152245 )
• there is over a 60% drop in mean erythrocyte cell number
decreased hematocrit ( J:152245 )
• hematocrit is decreased by half
decreased hemoglobin content ( J:152245 )
• hemoglobin is decreased by more than half
increased mean corpuscular volume ( J:152245 )
• corpuscular volume is increased by 20%
increased nucleated erythrocyte cell number ( J:152245 )
• 69 x 103 nucleated RBC per liter are found in the blood
thrombocytopenia ( J:152245 )
• platelet counts are about 40% of normal
reticulocytosis ( J:152245 )
• reticulocyte percentage is increased almost 50-fold in the blood

immune system
enlarged spleen ( J:152245 )
• mice have massive splenomegaly

integument
pallor ( J:152245 )
• homozygote newborns are easily distinguishable from controls by their extreme pallor

growth/size/body
enlarged spleen ( J:152245 )
• mice have massive splenomegaly




Genotype
MGI:4357834
ht2
Allelic
Composition		 Slc4a1tm1Phsl/Slc4a1+
Genetic
Background		 involves: 129 * 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc4a1tm1Phsl mutation (0 available); any Slc4a1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
reticulocytosis ( J:152245 )
• reticulocyte percentage is increased 3-fold in the blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory