About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(EIF1AX-PMS2*)685Tcar
transgene insertion 685, Trent Carrier
MGI:4357948
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(EIF1AX-PMS2*)685Tcar/0
Tg(TacLIZa)A1Jsh/0 		involves: C57BL/6 * SJL MGI:4358136
tg2
 		Tg(EIF1AX-PMS2*)685Tcar/0 involves: C57BL/6 * SJL MGI:4358135


Genotype
MGI:4358136
cx1
Allelic
Composition		 Tg(EIF1AX-PMS2*)685Tcar/0
Tg(TacLIZa)A1Jsh/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal DNA repair ( J:152364 )
• in mice expressing only the Tg(TacLIZa)A1Jsh (Big BlueTM transgene), the normal background mutation frequency was determined to be 1.62E-05 using DNA from liver, whereas tissue from double transgenic mice (expressing the Big BlueTM reporter transgene and Tg(EIF1AX-PMS2*)685Tcar (MophogeneTM)) displayed a mutation frequency of 4.0E-05 (2.5-fold higher than wild-type)

homeostasis/metabolism
abnormal DNA repair ( J:152364 )
• in mice expressing only the Tg(TacLIZa)A1Jsh (Big BlueTM transgene), the normal background mutation frequency was determined to be 1.62E-05 using DNA from liver, whereas tissue from double transgenic mice (expressing the Big BlueTM reporter transgene and Tg(EIF1AX-PMS2*)685Tcar (MophogeneTM)) displayed a mutation frequency of 4.0E-05 (2.5-fold higher than wild-type)




Genotype
MGI:4358135
tg2
Allelic
Composition		 Tg(EIF1AX-PMS2*)685Tcar/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:152364 )
• cell exhibit microsatellite instability, evident in samples taken from liver and ovary
• total mutation frequency in liver is 1.42%, consisting of expansions and contractions of microsatellites in contrast to none detected in liver samples from wild-type
abnormal mismatch repair ( J:152364 )
• defective mismatch repair (MMR) is exhibited, shown by microsatellite instability

homeostasis/metabolism
abnormal mismatch repair ( J:152364 )
• defective mismatch repair (MMR) is exhibited, shown by microsatellite instability




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory