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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(EIF1AX-PMS2*)685Tcar
transgene insertion 685, Trent Carrier
MGI:4357948
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(EIF1AX-PMS2*)685Tcar/0
Tg(TacLIZa)A1Jsh/0 		involves: C57BL/6 * SJL MGI:4358136
tg2
 		Tg(EIF1AX-PMS2*)685Tcar/0 involves: C57BL/6 * SJL MGI:4358135


Genotype
MGI:4358136
cx1
Allelic
Composition		 Tg(EIF1AX-PMS2*)685Tcar/0
Tg(TacLIZa)A1Jsh/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal DNA repair ( J:152364 )
• in mice expressing only the Tg(TacLIZa)A1Jsh (Big BlueTM transgene), the normal background mutation frequency was determined to be 1.62E-05 using DNA from liver, whereas tissue from double transgenic mice (expressing the Big BlueTM reporter transgene and Tg(EIF1AX-PMS2*)685Tcar (MophogeneTM)) displayed a mutation frequency of 4.0E-05 (2.5-fold higher than wild-type)

homeostasis/metabolism
abnormal DNA repair ( J:152364 )
• in mice expressing only the Tg(TacLIZa)A1Jsh (Big BlueTM transgene), the normal background mutation frequency was determined to be 1.62E-05 using DNA from liver, whereas tissue from double transgenic mice (expressing the Big BlueTM reporter transgene and Tg(EIF1AX-PMS2*)685Tcar (MophogeneTM)) displayed a mutation frequency of 4.0E-05 (2.5-fold higher than wild-type)




Genotype
MGI:4358135
tg2
Allelic
Composition		 Tg(EIF1AX-PMS2*)685Tcar/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:152364 )
• cell exhibit microsatellite instability, evident in samples taken from liver and ovary
• total mutation frequency in liver is 1.42%, consisting of expansions and contractions of microsatellites in contrast to none detected in liver samples from wild-type
abnormal mismatch repair ( J:152364 )
• defective mismatch repair (MMR) is exhibited, shown by microsatellite instability

homeostasis/metabolism
abnormal mismatch repair ( J:152364 )
• defective mismatch repair (MMR) is exhibited, shown by microsatellite instability




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory