Phenotypes associated with this allele

• Allele Symbol: Lat^{tm8.1(CD2,-ECFP)Mal}
• Allele Name: targeted mutation 8.1, Bernard Malissen
• Allele ID: MGI:4357957
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lat^tm8.1(CD2,-ECFP)Mal/Lat^tm8.1(CD2,-ECFP)Mal	involves: 129S2/SvPas * C57BL/6	MGI:4358065

Genotype
MGI:4358065

hm1

• Allelic Composition: Lat^{tm8.1(CD2,-ECFP)Mal}/Lat^{tm8.1(CD2,-ECFP)Mal}
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal lymphocyte morphology ( J:152149 )

• an abnormal lymphocyte population accumulates in the periphery with age

• the population lacks surface markers of T cells except Thy1 and ECFP expression

• a subset of these cells with low expression of Thy1 appear to be NK cells while the rest appear to be derived from a T cell lineage

• the population also has rearranged TCR gamma segments at 3 weeks of age and rearranged TCR delta segments at 52 weeks of age

• the rearrangements appear to be random with only 1 of 5 being productive

abnormal T cell receptor delta chain V(D)J recombination ( J:152149 )

• an abnormal Th1⁺ECFP⁺ lymphocyte population accumulates in the periphery with age

• in mice over 1 year of age, rearranged TCR Vdelta4 and Vdelta5 gene segments are detectable

abnormal T cell receptor gamma chain V-J recombination ( J:152149 )

• an abnormal Thy1⁺ECFP⁺ lymphocyte population accumulates in the periphery with age

• this population has TCR Vgamma to Jgamma1 rearrangements in the Cgamma1, Cgamma2 and Cgamma4 clusters

• the rearrangements appear to be random with only 1 of 5 being productive

increased double-negative T cell number ( J:152149 )

• double negative thymocyte numbers accumulate in the thymus due to the block in differentiation

arrested T cell differentiation ( J:152149 )

• T cell differentiation is almost entirely arrested at the DN3 stage

• an abnormal lymphocyte population accumulates in the periphery with age that has Thy1 expression but no surface TCR

hematopoietic system

abnormal lymphocyte morphology ( J:152149 )

• an abnormal lymphocyte population accumulates in the periphery with age

• the population lacks surface markers of T cells except Thy1 and ECFP expression

• a subset of these cells with low expression of Thy1 appear to be NK cells while the rest appear to be derived from a T cell lineage

• the population also has rearranged TCR gamma segments at 3 weeks of age and rearranged TCR delta segments at 52 weeks of age

• the rearrangements appear to be random with only 1 of 5 being productive

abnormal T cell receptor delta chain V(D)J recombination ( J:152149 )

• an abnormal Th1⁺ECFP⁺ lymphocyte population accumulates in the periphery with age

• in mice over 1 year of age, rearranged TCR Vdelta4 and Vdelta5 gene segments are detectable

abnormal T cell receptor gamma chain V-J recombination ( J:152149 )

• an abnormal Thy1⁺ECFP⁺ lymphocyte population accumulates in the periphery with age

• this population has TCR Vgamma to Jgamma1 rearrangements in the Cgamma1, Cgamma2 and Cgamma4 clusters

• the rearrangements appear to be random with only 1 of 5 being productive

increased double-negative T cell number ( J:152149 )

• double negative thymocyte numbers accumulate in the thymus due to the block in differentiation

arrested T cell differentiation ( J:152149 )

• T cell differentiation is almost entirely arrested at the DN3 stage

• an abnormal lymphocyte population accumulates in the periphery with age that has Thy1 expression but no surface TCR