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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CAG-EGFP,-Pax6*5a,-lacZ)1Stoy
transgene insertion 1, Anastassia Stoykova
MGI:4358071
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Pax6tm2Pgr/Pax6+
Tg(CAG-EGFP,-Pax6*5a,-lacZ)1Stoy/0
Tg(Dct-cre)1Apdn/0
involves: 129S1/Sv * 129X1/SvJ MGI:4358214
cn2
Tg(CAG-EGFP,-Pax6*5a,-lacZ)1Stoy/0
Tg(Dct-cre)1Apdn/0
Not Specified MGI:4358215


Genotype
MGI:4358214
cn1
Allelic
Composition
Pax6tm2Pgr/Pax6+
Tg(CAG-EGFP,-Pax6*5a,-lacZ)1Stoy/0
Tg(Dct-cre)1Apdn/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6tm2Pgr mutation (1 available); any Pax6 mutation (94 available)
Tg(CAG-EGFP,-Pax6*5a,-lacZ)1Stoy mutation (0 available)
Tg(Dct-cre)1Apdn mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• iris sphincter appearance is improved very slightly compared to Pax6tm2Pgr/+; Tg(Dct-cre) animals
• expression of transgenic Pax6 partially corrects iris length in Pax6tm2Pgr/+; Tg(Dct-cre) animals (length is 73% of wild-type)




Genotype
MGI:4358215
cn2
Allelic
Composition
Tg(CAG-EGFP,-Pax6*5a,-lacZ)1Stoy/0
Tg(Dct-cre)1Apdn/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-EGFP,-Pax6*5a,-lacZ)1Stoy mutation (0 available)
Tg(Dct-cre)1Apdn mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• no structural aberrations of ciliary body is observed in mice expressing this Pax6 isoform
• iris is indistinguishable from controls





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory