Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-EGFP,-Pax6,-lacZ)1Stoy
• Allele Name: transgene insertion 1, Anastassia Stoykova
• Allele ID: MGI:4358072
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pax6^tm2Pgr/Pax6^+ Tg(CAG-EGFP,-Pax6,-lacZ)1Stoy/0 Tg(Dct-cre)1Apdn/0	involves: 129S1/Sv * 129X1/SvJ	MGI:4358213
cn2	Tg(CAG-EGFP,-Pax6,-lacZ)1Stoy/0 Tg(Dct-cre)1Apdn/0	Not Specified	MGI:4358216

Genotype
MGI:4358213

cn1

• Allelic Composition: Pax6^tm2Pgr/Pax6⁺; Tg(CAG-EGFP,-Pax6,-lacZ)1Stoy/0; Tg(Dct-cre)1Apdn/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal ciliary body morphology ( J:152253 )

• ciliary body varies from normal in appearance to reduced folding compared to Pax6 ^tm2Pgr/+; Tg(Dct-cre)1Apdn animals

abnormal iris morphology ( J:152253 )

• iris sphincter appearance is significantly, but variably improved compared to Pax6 ^tm2Pgr/+; Tg(Dct-cre)1Apdn

iris hypoplasia ( J:152253 )

• expression of transgenic Pax6 corrects iris length almost completely in Pax6^tm2Pgr/+; Tg(Dct-cre)1Apdn animals (length is 92% of wild-type)

Genotype
MGI:4358216

cn2

• Allelic Composition: Tg(CAG-EGFP,-Pax6,-lacZ)1Stoy/0; Tg(Dct-cre)1Apdn/0
• Genetic Background: Not Specified

vision/eye

abnormal ciliary body morphology ( J:152253 )

• severe underfolding of ciliary body (CB) is observed in postnatal animals

• general atrophy of CB with flattened appearance of folds is detected under scanning electron microscopy observation

• the stromal and both epithelial layers normally found in the CB are present but atrophic and barely folded

abnormal iris morphology ( J:152253 )

• sphincter is significantly enlarged