Analysis Tools
nervous system
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• at 12 weeks, neurons exhibit age-dependent reduction in spine density unlike wild-type neurons
• mature cortical pyramidal neurons exhibit lower spine density than in wild-type neurons
• however, spine density is rescued by over-expression of Kalrn
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• AMPAR-mediated synaptic transmission is reduced in layer V pyramidal neurons from acute frontal cortical slices compared with wild-type slices
• AMPAR miniature excitatory postsynaptic currents (mEPSCs) frequency is reduced compared to in wild-type mice
• however, AMPAR mESPC amplitudes are normal
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• AMPAR miniature excitatory postsynaptic currents (mEPSCs) frequency is reduced compared to in wild-type mice
• however, AMPAR mESPC amplitudes are normal
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behavior/neurological
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• mice fail to exhibit improved performance between the first and second trial in a Morris water maze unlike wild-type mice
• however, spatial reference memory and working memory at 3 weeks are normal
• at 12 weeks, mice exhibit impaired working memory performance in a Y-maze compared to wild-type mice
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• at 12 weeks, mice exhibit increased spontaneous motor activity in an automated cage and in the Y-maze with intramaze cues compared with wild-type mice
• however, locomotor activity at 3 weeks is normal
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• mice spend less time on the social side and more time on the non-social side of a 3-chamber social behavior apparatus than wild-type mice
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homeostasis/metabolism
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• neurons fail to exhibit an increase in spine area 30-minutes post-APV treatment unlike similarly treated wild-type cells
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