Analysis Tools|
Allele Symbol Allele Name Allele ID |
Bcl11atm1Pwt targeted mutation 1, Philip W Tucker MGI:4358087 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following pIpC induction cultured precursor cells fail to produce plasmacytoid dendritic cells
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• following pIpC induction cultured precursor cells fail to produce plasmacytoid dendritic cells
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• mild decrease in the total number of cells in GM-CSF-supplemented cultures following pIpC treatment
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• following pIpC induction cultured precursor cells fail to produce plasmacytoid dendritic cells and in vivo
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• in Flt3L-supplemented cultures following pIpC induced deletion in hematopoietic stem cells and in vivo
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• following pIpC induction cultured precursor cells fail to produce plasmacytoid dendritic cells
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• mild decrease in the total number of cells in GM-CSF-supplemented cultures following pIpC treatment
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• following pIpC induction cultured precursor cells fail to produce plasmacytoid dendritic cells and in vivo
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• in Flt3L-supplemented cultures following pIpC induced deletion in hematopoietic stem cells and in vivo
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal red blood cell numbers, white blood cell numbers and hemoglobin content
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• granulocytes, T cells, macrophage conventional dendritic cells and dendritic cell progenitors not affected in spleen and bone marrow
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• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• also reduced in the spleen but not as severely as in the bone marrow
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• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• proportionate to the loss of plasmacytoid dendritic cell in bone marrow and spleen
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• about a 2-fold decrease in the bone marrow
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• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• also reduced in the spleen but not as severely as in the bone marrow
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• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• proportionate to the loss of plasmacytoid dendritic cell in bone marrow and spleen
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• following infection with human HSV strain 17
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• following infection with human HSV strain 17
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal red blood cell numbers and hemoglobin content
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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