All Phenotypes Sik3<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Sik3^em1Iiis/Sik3⁺	involves: C57BL/6J	MGI:5806623
ht2	Sik3^Slp/Sik3⁺	involves: C57BL/6J * C57BL/6N	MGI:5806616
ht3	Sik3^tm1.1Iiis/Sik3⁺	involves: C57BL/6N	MGI:5806622

Allelic Composition	Sik3^em1Iiis/Sik3⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sik3^em1Iiis mutation (0 available); any Sik3 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal sleep duration ( J:236598 )

• prolonged sleep time and shorter daily wake times

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal circadian sleep/wake cycle ( J:236598 )

• however, mice exhibit normal period

• under constant darkness, mice exhibit reduced wake time compared with wild-type mice

abnormal sleep duration ( J:236598 )

• prolonged sleep time and shorter daily wake times

• hypersomnia is more pronounced in the dark phase

• mice exhibit prominent wake responses to cage change, caffeine or modafinil

abnormal non-rapid eye movement sleep pattern ( J:236598 )

• increased non-rapid eye movement sleep (NREMS) time in both the light and dark phases, more so than in heterozygotes

• higher NREMS to total sleep ratio than in wild-type mice

• mice exhibit increased NREMS delta (slow-wave activity) density compared with wild-type mice

• 6 hours of sleep deprivation from the onset of the light phase increased non-rapid eye movement sleep (NREMS) delta power to a larger extent compared with wild-type mice

abnormal paradoxical sleep pattern ( J:236598 )

• lower rapid eye movement sleep (REMS) to total sleep ratio compared with wild-type mice

• longer time spent in REMS during the dark phase secondary to increased sleep amount and shorter REMS time during the light phase

nervous system

abnormal brain wave pattern ( J:236598 )

• after 6 hours of sleep deprivation, mice exhibit increased normal relative increase in delta power compared with wild-type mice

• mice exhibit increased non-rapid eye movement sleep delta (slow-wave activity) density compared with wild-type mice

• 6 hours of sleep deprivation from the onset of the light phase increased non-rapid eye movement sleep (NREMS) delta power to a larger extent compared with wild-type mice

• however, mice exhibit a normal relative increase in delta power after 2 or 4 hours sleep deprivation

Allelic Composition	Sik3^tm1.1Iiis/Sik3⁺
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sik3^tm1.1Iiis mutation (1 available); any Sik3 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal sleep duration ( J:236598 )

• prolonged sleep time and shorter daily wake times

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