Analysis Tools
immune system
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• mature single positive thymocytes
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• mature single positive thymocytes
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• in the axillary lymph nodes and Peyer's patches
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• 76% in the blood
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• 86% in the blood and 45% in the spleen
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• 88% in the blood and 26% in the spleen
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• in a competitive assay, the ratio of T cells to wild-type T cells is 1.5 to 1 in the blood and 1.2 to 1 in the spleen due to impaired homing to peripheral lymphoid organs while the ratio is 0.5 to 1 in the lymph node due to reduced emigration of T cells into the circulation after entry into the secondary lymph organs or nonlymphoid tissues
• emigration of mature thymocytes from the thymus into the spleen is reduced compared to emigration of wild-type cells
• however, mature T cells exhibit normal S1P-mediated transmigration across endothelial cells in vitro
• the number of mobilized thymocytes in response to CCL19 is lower than for wild-type cells
• single positive thymocytes exhibit reduced response to CXCL12 and CCL25 compared with wild-type cells
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• CD4+ T cells exhibit a lower response to CCL21a and CCL19 compared with wild-type cells
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• CD8+ T cells exhibit a hyper chemotactic response to S1P compared with wild-type cells
• CD8+ T cells exhibit a lower response to CCL21a compared with wild-type cells
• immature CD8+ T cells exhibit reduced response to CCR19 compared with wild-type cells
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hematopoietic system
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• mature single positive thymocytes
|
|
• mature single positive thymocytes
|
|
• in the axillary lymph nodes and Peyer's patches
|
|
• 76% in the blood
|
|
• 86% in the blood and 45% in the spleen
|
|
• 88% in the blood and 26% in the spleen
|
|
• in a competitive assay, the ratio of T cells to wild-type T cells is 1.5 to 1 in the blood and 1.2 to 1 in the spleen due to impaired homing to peripheral lymphoid organs while the ratio is 0.5 to 1 in the lymph node due to reduced emigration of T cells into the circulation after entry into the secondary lymph organs or nonlymphoid tissues
• emigration of mature thymocytes from the thymus into the spleen is reduced compared to emigration of wild-type cells
• however, mature T cells exhibit normal S1P-mediated transmigration across endothelial cells in vitro
• the number of mobilized thymocytes in response to CCL19 is lower than for wild-type cells
• single positive thymocytes exhibit reduced response to CXCL12 and CCL25 compared with wild-type cells
|
|
• CD4+ T cells exhibit a lower response to CCL21a and CCL19 compared with wild-type cells
|
|
• CD8+ T cells exhibit a hyper chemotactic response to S1P compared with wild-type cells
• CD8+ T cells exhibit a lower response to CCL21a compared with wild-type cells
• immature CD8+ T cells exhibit reduced response to CCR19 compared with wild-type cells
|
endocrine/exocrine glands
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• mature single positive thymocytes
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