Phenotypes associated with this allele

• Allele Symbol: Tg(Pbsn-ERG*)1Vv
• Allele Name: transgene insertion 1, Valeri Vasioukhin
• Allele ID: MGI:4358243
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Pbsn-ERG*)1Vv/0	involves: 129S1/SvImJ * C57BL/6J * CBA	MGI:5705650
tg2	Tg(Pbsn-ERG*)1Vv/0	involves: 129/Sv * C57BL/6J * CBA	MGI:4358248

Genotype
MGI:5705650

tg1

• Allelic Composition: Tg(Pbsn-ERG*)1Vv/0
• Genetic Background: involves: 129S1/SvImJ * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:222916 )

♂ • shorter lifespan than wild-type mice, with mice beginning to die before 20 months of age and none surviving beyond 35 months of age

neoplasm

increased prostate gland tumor incidence ( J:222916 )

♂ • about 50% of mice 2 years of age and older develop prostate tumors

♂ • tumors include adenocarcinomas, sarcomatoid carcinomas (epithelial-mesenchymal transition-like epithelial tumor), and stromal-type tumors

increased prostate gland adenocarcinoma incidence ( J:222916 )

♂ • adenocarcinomas are composed primarily of luminal cells although small numbers of basal cells are seen close to the margins of the tumors

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:222916 )

♂ • about 50% of mice 2 years of age and older develop prostate tumors

♂ • tumors include adenocarcinomas, sarcomatoid carcinomas (epithelial-mesenchymal transition-like epithelial tumor), and stromal-type tumors

increased prostate gland adenocarcinoma incidence ( J:222916 )

♂ • adenocarcinomas are composed primarily of luminal cells although small numbers of basal cells are seen close to the margins of the tumors

reproductive system

increased prostate gland tumor incidence ( J:222916 )

♂ • about 50% of mice 2 years of age and older develop prostate tumors

♂ • tumors include adenocarcinomas, sarcomatoid carcinomas (epithelial-mesenchymal transition-like epithelial tumor), and stromal-type tumors

increased prostate gland adenocarcinoma incidence ( J:222916 )

♂ • adenocarcinomas are composed primarily of luminal cells although small numbers of basal cells are seen close to the margins of the tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:222916

Genotype
MGI:4358248

tg2

• Allelic Composition: Tg(Pbsn-ERG*)1Vv/0
• Genetic Background: involves: 129/Sv * C57BL/6J * CBA

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:131932 )

♂ • by 5-6 months of age, prostatic intraepithelial neoplasia (PIN) lesions are observed in ventral prostate; cells in these foci display epithelial nuclear pleomorphism and loss of polarization

♂ • number of lesions and cellular pleomorphism increase with mouse age; percentage of cells with nucleolomegaly increases with age

endocrine/exocrine glands

abnormal prostate gland epithelium morphology ( J:131932 )

♂ • basal cells are surrounded by abnormally accumulating luminal cells and become displaced away from the stromal cell compartment; direct contact between luminal cells and the basement membrane is observed by electron microscopy

♂ • ratio of basal cells to total prostate epithelial cells is significantly decreased compared to controls

♂ • epithelial compartment exhibits a small but significant increase in proportion of proliferating cells compared to controls

increased prostate intraepithelial neoplasia incidence ( J:131932 )

♂ • by 5-6 months of age, prostatic intraepithelial neoplasia (PIN) lesions are observed in ventral prostate; cells in these foci display epithelial nuclear pleomorphism and loss of polarization

♂ • number of lesions and cellular pleomorphism increase with mouse age; percentage of cells with nucleolomegaly increases with age

reproductive system

abnormal prostate gland epithelium morphology ( J:131932 )

♂ • basal cells are surrounded by abnormally accumulating luminal cells and become displaced away from the stromal cell compartment; direct contact between luminal cells and the basement membrane is observed by electron microscopy

♂ • ratio of basal cells to total prostate epithelial cells is significantly decreased compared to controls

♂ • epithelial compartment exhibits a small but significant increase in proportion of proliferating cells compared to controls

increased prostate intraepithelial neoplasia incidence ( J:131932 )

♂ • by 5-6 months of age, prostatic intraepithelial neoplasia (PIN) lesions are observed in ventral prostate; cells in these foci display epithelial nuclear pleomorphism and loss of polarization

♂ • number of lesions and cellular pleomorphism increase with mouse age; percentage of cells with nucleolomegaly increases with age